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For
from Section VII - Genetics
Published online by Cambridge University Press: 25 November 2021
In order to discuss the benefits of preimplantation genetic testing for aneuploidies (PGT-A) for recurrent implantation failure (RIF), we first need to define this condition. However, despite extensive research and due to numerous contributing factors, there is not yet a single agreed-upon definition. It is well established that the major cause of pregnancy loss is chromosomal aneuploidy. Sato et al. showed that even though PGT-A could not improve the live birth rate per patient, it reduced the overall incidence of pregnancy loss in patients with repeated implantation failure (RIF) [1]. Pirtea et al. had a different perspective, suggesting that true RIF is rare for those patients with the ability to produce euploid blastocysts. In analyzing 4,515 patients, 94.9% of them achieved clinical pregnancy in up to three consecutive transfers of frozen single euploid embryos [2].
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