Book contents
- Cambridge Handbook of Pain Medicine
- Cambridge Handbook of Pain Medicine
- Copyright page
- Contents
- Contributors
- Pain Handbook Introduction
- Part I Introduction to Pain: Pain Signaling Pathways
- Part II Common Categories of Pharmacologic Medications to Treat Chronic Pain
- Part III Chronic Pain Conditions Head and Neck
- Part IV Spine
- Part V Extremities
- Chapter 18 Carpal Tunnel Syndrome
- Chapter 19 Adhesive Capsulitis of the Shoulder
- Chapter 20 Thoracic Outlet Syndrome
- Chapter 21 Osteoarthritic Hip Pain
- Chapter 22 Osteoarthritic Knee Pain
- Chapter 23 Chronic Ankle and Foot Pain
- Chapter 24 Plantar Fasciitis
- Chapter 25 Phantom Limb Pain
- Part VI Misc
- Part VII Adjunctive Therapy
- Index
- References
Chapter 22 - Osteoarthritic Knee Pain
from Part V - Extremities
Published online by Cambridge University Press: 01 December 2023
Book contents
- Cambridge Handbook of Pain Medicine
- Cambridge Handbook of Pain Medicine
- Copyright page
- Contents
- Contributors
- Pain Handbook Introduction
- Part I Introduction to Pain: Pain Signaling Pathways
- Part II Common Categories of Pharmacologic Medications to Treat Chronic Pain
- Part III Chronic Pain Conditions Head and Neck
- Part IV Spine
- Part V Extremities
- Chapter 18 Carpal Tunnel Syndrome
- Chapter 19 Adhesive Capsulitis of the Shoulder
- Chapter 20 Thoracic Outlet Syndrome
- Chapter 21 Osteoarthritic Hip Pain
- Chapter 22 Osteoarthritic Knee Pain
- Chapter 23 Chronic Ankle and Foot Pain
- Chapter 24 Plantar Fasciitis
- Chapter 25 Phantom Limb Pain
- Part VI Misc
- Part VII Adjunctive Therapy
- Index
- References
Summary
Osteoarthritis is a common etiology of chronic knee pain and disability associated with aging, weight, and physical inactivity. Global radiographic evidence of knee OA is present in 28.7% of people over 40 years old.Global symptomatic evidence of knee OA is present in 12.4% of people over 40 years old. “Wear and tear” damage to hip joint leading to dysfunctional ECM reorganization leads to chronic onset of pain that is worse with use and associated with decreased knee mobility. Years of conservative treatment with exercise, weight loss, and oral anti-inflammatories can mitigate the disease progression, but severe cases may require intraarticular injections or knee arthroplasty. Some promising injections hope to better manage chronic symptoms by reversing the course of the disease; however, knee arthroplasty remains a gold standard treatment of severe knee OA.
- Type
- Chapter
- Information
- Cambridge Handbook of Pain Medicine , pp. 173 - 180Publisher: Cambridge University PressPrint publication year: 2023
References
Dillon, CF, Rasch, EK, Gu, Q, Hirsch, R. Prevalence of knee osteoarthritis in the United States: Arthritis data from the Third National Health and Nutrition Examination Survey 1991–94. J Rheumatol. 2006;33(11):2271–2279.Google ScholarPubMed
Federal Interagency Forum on Aging-Related Statistics. Older Americans 2016: Key indicators of well-being. US Government Printing Office; 2016.Google Scholar
Felson, DT, Niu, J, Clancy, M et al. Effect of recreational physical activities on the development of knee osteoarthritis in older adults of different weights: The Framingham study. Arthritis Rheum. 2007;57:6–12.CrossRefGoogle ScholarPubMed
Barbour, KE, Hootman, JM, Helmick, CG et al. Meeting physical activity guidelines and the risk of incident knee osteoarthritis: A population-based prospective cohort study. Arthritis Care Res (Hoboken). 2014;66:139–146.CrossRefGoogle ScholarPubMed
Mora, JC, Przkora, R, Cruz-Almeida, Y. Knee osteoarthritis: Pathophysiology and current treatment modalities. J Pain Res. 2018;11:2189–2196.CrossRefGoogle ScholarPubMed
Heidari, B. Knee osteoarthritis diagnosis, treatment and associated factors of progression: Part II. Caspian J Intern Med. 2011;2(3):249–255.Google ScholarPubMed
Cui, A, Li, H, Wang, D et al. Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine. 2020;29–30:100587. doi: 10.1016/j.eclinm.2020.100587.CrossRefGoogle ScholarPubMed
Chen, D, Shen, J, Zhao, W et al. Osteoarthritis: Toward a comprehensive understanding of pathological mechanism. Bone Res. 2017;5:16044. doi: 10.1038/boneres.2016.44.CrossRefGoogle Scholar
Zhang, W, Doherty, M, Peat, G et al. EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis. Ann Rheum Dis. 2010;69(3):483–489.CrossRefGoogle ScholarPubMed
Webb, EJ, Osmotherly, PG, Baines, SK. Effect of dietary weight loss and macronutrient intake on body composition and physical function in adults with knee osteoarthritis: A systematic review. J Nutr Gerontol Geriatr. 2022;41(2):103–125.CrossRefGoogle ScholarPubMed
Robson, EK, Hodder, RK, Kamper, SJ et al. Effectiveness of weight-loss interventions for reducing pain and disability in people with common musculoskeletal disorders: A systematic review with meta-analysis. J Orthop Sports Phys Ther. 2020;50(6):319–333.CrossRefGoogle ScholarPubMed
Landsmeer, MLA, de Vos, BC, van der Plas, P et al. Effect of weight change on progression of knee OA structural features assessed by MRI in overweight and obese women. Osteoarthritis Cartilage. 2018;26(12):1666–1674.CrossRefGoogle ScholarPubMed
Goh, SL, Persson, MSM, Stocks, J et al. Efficacy and potential determinants of exercise therapy in knee and hip osteoarthritis: A systematic review and meta-analysis. Ann Phys Rehabil Med. 2019;62(5):356–365.CrossRefGoogle ScholarPubMed
Raposo, F, Ramos, M, Lúcia Cruz, A. Effects of exercise on knee osteoarthritis: A systematic review. Musculoskeletal Care. 2021;19(4):399–435.CrossRefGoogle ScholarPubMed
Fransen, M, McConnell, S, Harmer, AR et al. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2015;1:CD004376.Google ScholarPubMed
Puljak, L, Marin, A, Vrdoljak, D et al. Celecoxib for osteoarthritis. Cochrane Database Syst Rev. 2017;5(5):CD009865.Google ScholarPubMed
Towheed, TE, Maxwell, L, Judd, MG et al. Acetaminophen for osteoarthritis. Cochrane Database Syst Rev. 2006;(1):CD004257. doi: 10.1002/14651858.CD004257.pub2.Google ScholarPubMed
Toupin April, K, Bisaillon, J, Welch, V et al. Tramadol for osteoarthritis. Cochrane Database Syst Rev. 2019;5(5):CD005522.Google ScholarPubMed
da Costa, BR, Nüesch, E, Kasteler, R et al. Oral or transdermal opioids for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2014;(9):CD003115. doi: 10.1002/14651858.CD003115.pub4.Google ScholarPubMed
Towheed, TE, Maxwell, L, Anastassiades, TP et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. 2005;(2):CD002946. doi: 10.1002/14651858.CD002946.pub2.Google ScholarPubMed
Singh, JA, Noorbaloochi, S, MacDonald, R, Maxwell, LJ. Chondroitin for osteoarthritis. Cochrane Database Syst Rev. 2015;1(1):CD005614.Google ScholarPubMed
Jüni, P, Hari, R, Rutjes, AW et al. Intra-articular corticosteroid for knee osteoarthritis. Cochrane Database Syst Rev. 2015;(10):CD005328. doi: 10.1002/14651858.CD005328.pub3.Google ScholarPubMed
McAlindon, TE, LaValley, MP, Harvey, WF et al. Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: A randomized clinical trial. JAMA. 2017;317:1967–1975.CrossRefGoogle ScholarPubMed
McLarnon, M, Heron, N. Intra-articular platelet-rich plasma injections versus intra-articular corticosteroid injections for symptomatic management of knee osteoarthritis: Systematic review and meta-analysis. BMC Musculoskelet Disord. 2021;22(1):550. doi: 10.1186/s12891-021-04308-3.CrossRefGoogle ScholarPubMed
Meheux, CJ, McCulloch, PC, Lintner, DM, Varner, KE, Harris, JD. Efficacy of intra-articular platelet-rich plasma injections in knee osteoarthritis: A systematic review. Arthroscopy. 2016;32(3):495–505.CrossRefGoogle ScholarPubMed
Bellamy, N, Campbell, J, Robinson, V et al. Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006;(2):CD005321. doi: 10.1002/14651858.CD005321.pub2.Google ScholarPubMed
Richette, P, Chevalier, X, Ea, HK et al. Hyaluronan for knee osteoarthritis: An updated meta-analysis of trials with low risk of bias. RMD Open. 2015;1(1):e000071.CrossRefGoogle ScholarPubMed
Xing, D, Wang, B, Liu, Q et al. Intra-articular hyaluronic acid in treating knee osteoarthritis: A PRISMA-compliant systematic review of overlapping meta-analysis. Sci Rep. 2016;6:32790. doi: 10.1038/srep32790.CrossRefGoogle ScholarPubMed
Peck, J, Slovek, A, Miro, P et al. A comprehensive review of viscosupplementation in osteoarthritis of the knee. Orthop Rev (Pavia). 2021;13(2):25549. doi: 10.52965/001c.25549.CrossRefGoogle ScholarPubMed
Di Matteo B, Vandenbulcke F, Vitale ND et al. Minimally manipulated mesenchymal stem cells for the treatment of knee osteoarthritis: A systematic review of clinical evidence. Stem Cells Int. 2019;2019:1735242. doi: 10.1155/2019/1735242.CrossRefGoogle Scholar