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3.7.11 - Anti-fungal Therapies

from Section 3.7 - Infection and Immunity

Published online by Cambridge University Press:  27 July 2023

By
James McKinlay  and
Alexander Fletcher
Edited by
Ned Gilbert-Kawai ,
Debashish Dutta  and
Carl Waldmann
Ned Gilbert-Kawai
Affiliation:
The Royal Liverpool Hospital
Debashish Dutta
Affiliation:
Princess Alexandra Hospital NHS Trust, Harlow
Carl Waldmann
Affiliation:
Royal Berkshire Hospital, Reading
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Summary

Key Learning Points

  1. 1. Invasive fungal infections are associated with high mortality.

  2. 2. The majority of fungal infections are opportunistic in nature.

  3. 3. Resistance to anti-fungal agents is rare and difficult to detect.

  4. 4. Candida species are the most common cause of fungal infections.

  5. 5. Blood cultures have a low sensitivity for detecting fungaemias.

Keywords

anti-fungalPneumocystisazolespolyenesechinocandins
Type
Chapter
Information
Intensive Care Medicine
The Essential Guide
 , pp. 282 - 284
Publisher: Cambridge University Press
Print publication year: 2021

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References

References and Further Reading

Greenwood, D, Finch, R, Davey, P, Wilcox, M. General properties of antimicrobial agents. In: Greenwood, D, Finch, R, Davey, P, Wilcox, M (eds). Antimicrobial Chemotherapy, 5th edn. Oxford: Oxford University Press; 2008. pp. 67–77.Google Scholar
Lepak, A, Andes, D. Fungal sepsis: optimizing antifungal therapy in the critical care setting. Crit Care Clin 2011;27:123–47.CrossRefGoogle ScholarPubMed
Moghnieh, R, Kanafani, ZA, Kanj, SS. Antifungal use in intensive care units: another uncertainty that highlights the need for precision medicine. J Thorac Dis 2016;8:E1672–5.CrossRefGoogle ScholarPubMed
Timsit, J-F, Perner, A, Bakker, J, et al. Year in review in Intensive Care Medicine 2014: III. Severe infections, septic shock, healthcare-associated infections, highly resistant bacteria, invasive fungal infections, severe viral infections, Ebola virus disease and paediatrics. Intensive Care Med 2015;41:575–88.CrossRefGoogle ScholarPubMed

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