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Case 33 - Drug-Induced Myasthenia Gravis: Immune Checkpoint Inhibitor (ICI)-Related

from Disorders of the Neuromuscular Junction

Published online by Cambridge University Press:  29 November 2024

Jessica E. Hoogendijk
Affiliation:
University Medical Center Utrecht
Marianne de Visser
Affiliation:
Amsterdam University Medical Center
Pieter A. van Doorn
Affiliation:
Erasmus MC, University Medical Center, Rotterdam
Erik H. Niks
Affiliation:
Leiden University Medical Center
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Summary

A 73-year-old man was referred by his oncologist because of dyspnoea occurring for one and a half weeks, and high CK levels (1341 U/L). For four years he was treated for a melanoma with pulmonary and cerebral metastases. Treatment included nivolumab that had been started three months previously. The dyspnoea was worse on exertion and when lying down. He also experienced some difficulties speaking clearly, and choking had occurred a few times during the past week. He had no diplopia. The complaints did not fluctuate. There was some recent myalgia, but he had not noticed any muscle weakness.

Type
Chapter
Information
Neuromuscular Disease
A Case-Based Approach
, pp. 163 - 164
Publisher: Cambridge University Press
Print publication year: 2024

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References

Suggested Reading

Astaras, C, de Micheli, R, Moura, B, Hundsberger, T, Hottinger, AF. Neurological adverse events associated with immune checkpoint inhibitors: diagnosis and management. Curr Neurol Neurosci Rep 2018;18(1):3. doi: 10.1007/s11910-018-0810-1. PMID: 29392441.CrossRefGoogle ScholarPubMed
Huang, YT, Chen, YP, Lin, WC, Su, WC, Sun, YT. Immune checkpoint inhibitor-induced myasthenia gravis. Front Neurol 2020;11:634. doi: 10.3389/fneur.2020.00634. PMID: 32765397; PMCID: PMC7378376.CrossRefGoogle ScholarPubMed
Narayanaswami, P, Sanders, DB, Wolfe, G, et al. International consensus guidance for management of myasthenia gravis: 2020 Update. Neurology 2021;96(3):114122. doi: 10.1212/WNL.0000000000011124. Epub 2020 Nov 3. PMID: 33144515; PMCID: PMC7884987.CrossRefGoogle ScholarPubMed
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Safa, H, Johnson, DH, Trinh, VA, et al. Immune checkpoint inhibitor related myasthenia gravis: single center experience and systematic review of the literature. J Immunother Cancer 2019;7(1):319. doi: 10.1186/s40425-019-0774-y. PMID: 31753014; PMCID: PMC6868691.CrossRefGoogle ScholarPubMed
Schneider, BJ, Naidoo J, Santomasso BD et al. Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: ASCO Guideline Update. J Clin Oncol. 2021 Dec 20;39(36):4073–4126. doi: 10.1200/JCO.21.01440. Epub 2021 Nov 1. Erratum in: J Clin Oncol. 2022 Jan 20;40(3):315. PMID: 34724392.Google Scholar

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