Preface

Summary

Translational motion in solution (e.g., diffusion, flow or advection) plays a central role in science. Self-diffusion can be rightfully considered as being the most fundamental form of transport at the molecular level and, consequently, it lies at the heart of many chemical reactions and can even govern the kinetics. Diffusion, due to its very ubiquity, is encountered in a myriad of scientific studies ranging from diseases to separation science and nanotechnology. Further, the translational motion of a species not only reflects intrinsic properties of the species itself (e.g., hydrodynamics), but can also shed light on the surrounding environment (e.g., intermolecular dynamics or motional restriction). Consequently, being able to study and ultimately understand the translational motion of molecules and molecular systems in their native environment is of inestimable scientific value.

Measuring translational motion at the molecular level presents special difficulties since labelling (e.g., radiotracers) or the introduction of thermodynamic gradients (which leads to mutual diffusion and consequently irreversible thermodynamics) in the measurement process can have deleterious effects on the outcome. Also, in many instances it is of interest to measure the diffusion of species at quite high concentrations. Fortunately, nuclear magnetic resonance (NMR) provides a means of unparalleled utility and convenience for performing non-invasive measurements of translational motion. Of particular significance is that, in general, the species of interest inherently contain NMR-sensitive nuclei and thus sample preparation generally requires nothing more than placing the sample into the NMR spectrometer.