Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-14T09:57:37.466Z Has data issue: false hasContentIssue false

Chapter 4 - Vitamin B12 and Folate Deficiencies in Pregnancy

from Section 2 - Cytopenia

Published online by Cambridge University Press:  01 February 2018

By
Alesia Khan  and
Susan Robinson
Edited by
Sue Pavord  and
Beverley Hunt
Sue Pavord
Affiliation:
University of Oxford
Beverley Hunt
Affiliation:
King's College London
Get access
Type
Chapter
Information
The Obstetric Hematology Manual , pp. 29 - 39
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Murphy, MM, Molloy, A, Ueland, PM et al. Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring. The Journal of Nutrition 2007; 137: 1863–1866.CrossRefGoogle ScholarPubMed
Vanderjagt, D, Ujah, I, Ikeh, EI et al. Assessment of the vitamin B12 status of pregnant women in Nigeria using plasma holotranscobalamin. ISRN Obstetrics and Gynecology 2011: 365894.Google Scholar
Green, R. Physiology, dietary sources, and requirements. Encyclopedia of Human Nutrition, 3rd edn, Vol 4. USA: Elsevier; 2013: 351–356.Google Scholar
Sobczyńska-Malefora, A, Gorska, R, Pelisser, M et al. An audit of holotranscobalamin (“Active” B12) and methylmalonic acid assays for the assessment of vitamin B12 status: Application in a mixed patient population. Clinical Biochemistry 2014; 47: 82–86.Google Scholar
Stabler, S. Vitamin B12 deficiency. New England Journal of Medicine 2013; 368:149–160.Google Scholar
Reynolds, E. Vitamin B12, folic acid, and the nervous system. The Lancet Neurology 2006; 5(11): 949–960.Google Scholar
Gauchan, D, Joshi, N, Singh Gill, A, et al. Does an elevated serum vitamin B12 level mask actual vitamin B12 deficiency in myeloproliferative disorders? Clinical Lymphoma, Myeloma & Leukemia 2012; 12(4): 269–273.CrossRefGoogle ScholarPubMed
Harmening, D. Clinical Hematology and Fundamentals of Hemostasis, 4th edn, Vol 7. USA: The Taber’s publisher; 2002: 112–119.Google Scholar
Provan, D, Singer, C, Baglin, T, Dokal, I. Oxford Handbook of Clinical Hematology, 3rd edn, Vol 2. Oxford: Oxford University Press; 2009: 46–47.CrossRefGoogle Scholar
Gröber, U, Kisters, K, Schmidt, J. Neuroenhancement with vitamin B12 underestimated neurological significance. Nutrients 2013; 5: 5031–5045.CrossRefGoogle ScholarPubMed
Kaushansky, K, Lichtman, M, Beutler, E et al. Williams Hematology, 8th edn, Vol 41. USA: McGraw Hill Medical; 2008: 538–545.Google Scholar
Devalia, V, Hamilton, M, Molloy, A. Guidelines for the diagnosis and treatment of cobalamin and folate disorders. British Journal of Hematology 2014; 166: 496–513.Google Scholar
Quadros, E. Advances in the understanding of cobalamin assimilation and metabolism. British Journal of Hematology 2010; 148: 195–204.CrossRefGoogle ScholarPubMed
Black, M. Effects of vitamin B12 and folate deficiency on brain development in children. Food and Nutrition Bulletin 2008; 29(2 Suppl): S126–S131.CrossRefGoogle ScholarPubMed
Carmel, R. How I treat cobalamin (vitamin B12) deficiency. Blood 2008; 112: 2214–2221.Google Scholar
Lindenbaum, J, Healton, E, Savage, D. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. New England Journal of Medicine 1988; 318: 1720–1728.Google Scholar
Solomon, L. Disorders of cobalamin (Vitamin B12) metabolism: Emerging concepts in pathophysiology, diagnosis and treatment. Blood Reviews 2007; 21: 113–130.Google Scholar
Clarke, R, Sherliker, P, Hin, H. Detection of vitamin B12 deficiency in older people by measuring vitamin B12 or the active fraction of vitamin B12, holotranscobalamin. Clinical Chemistry 2007; 53(5); 963–970.CrossRefGoogle ScholarPubMed
Valente, E, Scott, J, Ueland, P et al. Diagnostic accuracy of holotranscobalamin, methylmalonic acid, serum cobalamin, and other indicators of tissue vitamin B12 status in the elderly. Clinical Chemistry 2011; 57(6): 856–863.CrossRefGoogle ScholarPubMed
Sobczyńska-Malefora, A, Harrington, D, Voong, K et al. Plasma and red cell reference intervals of 5-methyltetrahydrofolate of healthy adults in whom biochemical functional deficiencies of folate and vitamin B12 had been excluded. Advances in Hematology 2014: 465623. doi:10.1155/2014/465623.CrossRefGoogle Scholar
Clinical Knowledge Summaries. Anemia – B12 and folate. https://cks.nice.org.uk/anaemia-b12-and-folate-deficiency#!topicsummaryGoogle Scholar
British National Formulary (BNF). http://www.medicinescomplete.com/mc/bnf/current/PHP5867-drugs-used-in-megaloblastic-anemias.htmGoogle Scholar
Yakoob, M, Bhutta, Z. Effect of routine iron supplementation with or without folic acid on anemia during pregnancy. BMC Public Health 2011; 11(Suppl 3): S21.Google Scholar
Short, R. UK government consults public on compulsory folate fortification. BMJ 2006; 332(7546): 873.Google Scholar
Rain, J, Blot, I, Tcherina, G. Folic acid deficiency in developing nations. In Cooper, BA et al. (eds) Folates and Cobalamins, Bertin, Heidelberg: spinger-verlag; 1989: 171–177.CrossRefGoogle Scholar
De Benoist, B. Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food and Nutrition Bulletin 2008; 29(2): S238–244.CrossRefGoogle ScholarPubMed
Greenberg, J, Bell, S, Guan, Y et al. Folic acid supplementation and pregnancy: more than just neural tube defect prevention. Reviews in Obstetrics and Gynecology 2011; 4(2): 52–59.Google Scholar
Ueland, PM, Vollset, SE. Homocysteine and folate in pregnancy. Clinical Chemistry 2004; 50(8): 1293–1294.Google Scholar
Fuller-Deets, M, Dingwall, R. The Ethical Implications of Options for Improving the Folate Intake of Women of Reproductive Age. Food Standards Agency report produced by the Institute for Science and Society, University of Nottingham. 2007; 17: 1–56.Google Scholar
Wilson, RD, Johnson, JA, Wyatt, P et al. Genetics Committee of the Society of Obstetricians and Gynecologists of Canada and The Motherrisk Program. Pre-conceptional vitamin/folic acid supplementation 2007: the use of folic acid in combination with a multivitamin supplement for the prevention of neural tube defects and other congenital anomalies. Journal of Obstetrics and Gynaecology Canada 2007; 29: 1003–1026.Google Scholar
Castillo-Lancellotti, C, Tur, J, Uauy, R. Impact of folic acid fortification of flour on neural tube defects: a systematic review. Public Health Nutrition 2013; 16(5): 901–911.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×