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Chapter 61 - Herpes Simplex Virus Infection in Pregnancy

from Section 11 - Infectious Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Amira El-Messidi
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 23-year-old primigravida is referred for consultation at 21+5 weeks’ gestation with a new onset of genital lesions. Her referring physician informs you that she has no history of genital herpes and that her obstetric progress has been unremarkable. All routine prenatal screening tests and investigations have been normal. She has no obstetric complaints and indicates the fetus is active.

Keywords

Herpes simplex virus, pregnancyPrimary, nonprimary, recurrent genital herpes simplex infectionRisk factorsDiagnosis, investigationsPrenatal counselingMother-to-child, perinatal transmissionAntepartum, intrapartum, postpartum managementTreatment, pharmacologyDrug mechanism of actionNeonatal herpes simplex infectionObstetric deliveryRupture of membranesNewborn care, breastfeeding
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 787 - 795
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

American College of Obstetricians and Gynecologists' Committee on Practice Bulletins – Obstetrics. Management of genital herpes in pregnancy: ACOG Practice Bulletin, No. 220. Obstet Gynecol. 2020;135(5):e193–e202.CrossRefGoogle Scholar
Canadian guidelines on sexually transmitted infections – management and treatment of specific infections – genital herpes simplex virus (HSV) infections. Available at www.canada.ca/en/public-health/services/infectious-diseases/sexual-health-sexually-transmitted-infections/canadian-guidelines/sexually-transmitted-infections/canadian-guidelines-sexually-transmitted-infections-32.html. Accessed August 27, 2020.Google Scholar
Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. Available at www.cdc.gov/std/tg2015/genital-ulcers.htm. Accessed August 29, 2020.Google Scholar
Feltner, C, Grodensky, C, Ebel, C, et al. serologic screening for genital herpes: an updated evidence report and systematic review for the US Preventive Services Task Force. JAMA. 2016;316(23):2531–2543.CrossRefGoogle ScholarPubMed
Foley, E, Clarke, E, Beckett, VA, et al. Guideline: management of genital herpes in pregnancy. R Coll Obstet Gynaecol 2014. Available at www.rcog.org.uk/globalassets/documents/guidelines/management-genital-herpes.pdf. Accessed August 27, 2020.Google Scholar
Hollier, LM, Wendel, GD. Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection. Cochrane Database Syst Rev. 2008;(1):CD004946.Google Scholar
Lee, R, Nair, M. Diagnosis and treatment of herpes simplex 1 virus infection in pregnancy. Obstet Med. 2017;10(2):58–60.CrossRefGoogle ScholarPubMed
Money, DM, Steben, M. No. 208 – guidelines for the management of herpes simplex virus in pregnancy. J Obstet Gynaecol Can. 2017;39(8): e199–e205.Google Scholar
Patel, R, Kennedy, OJ, Clarke, E, et al. 2017 European guidelines for the management of genital herpes. Int J STD AIDS. 2017;28(14):1366–1379.CrossRefGoogle ScholarPubMed
Stephenson-Famy, A, Gardella, C. Herpes simplex virus infection during pregnancy. Obstet Gynecol Clin North Am. 2014;41(4):601–614.Google Scholar

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