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from Section 8 - Hematology–Oncology Emergencies
Published online by Cambridge University Press: 02 November 2023
Thrombotic microangiopathies (TMA) are a group of conditions characterized by excessive platelet activation, resulting in microvascular thrombi and platelet consumption (thrombocytopenia). The thrombosed microvasculature shears red blood cells (RBCs), causing microangiopathic hemolytic anemia. Primary TMAs include thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS), while secondary TMAs result from infection, pregnancy, malignancy, drugs and toxins, among other causes.
TMAs do not directly involve the coagulation cascade, and therefore do not prolong coagulation studies. Microthrombi may result in ischemic complications in any organ system.
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