Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-28T01:03:07.335Z Has data issue: false hasContentIssue false

Part 5 - New developments in stem-cell research

Published online by Cambridge University Press:  05 July 2013

Edited by
Carlos Simón ,
Antonio Pellicer  and
Renee Reijo Pera
Carlos Simón
Affiliation:
Instituto Valenciano de Infertilidad, University of Valencia
Antonio Pellicer
Affiliation:
Instituto Valenciano de Infertilidad, University of Valencia
Renee Reijo Pera
Affiliation:
Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine
Get access

Summary

This chapter presents recent advances in the study of cell reprogramming within the broader context of organ regeneration research in certain animal models. It summarizes current approaches to investigate reprogramming, dedifferentiation, and transdifferentiation, and discusses the mechanisms that underlie the erasure of epigenetic memory during cellular reprogramming. Dedifferentiation entails a stable change in cell fate (reprogramming) so that the resulting cell type represents earlier steps in the cell's developmental history, either molecularly or functionally. The term lineage conversion or transdifferentiation is used to describe changes in cell fate that do not involve a gain in cell potency. Comparing how natural instances of cell reprogramming and their experimental counterparts are regulated will surely identify commonalities, but also context-specific differences. In addition to bettering our understanding of fascinating biological phenomena, research on induced reprogramming to pluripotency and direct cell fate conversion is likely to have profound biomedical implications.
Type
Chapter
Information
Stem Cells in Reproductive Medicine
Basic Science and Therapeutic Potential
 , pp. 152 - 179
Publisher: Cambridge University Press
Print publication year: 2013

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×