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Biology of personality disorders

Published online by Cambridge University Press:  18 September 2015

S. Tuinier  and
W.M.A. Verhoeven
S. Tuinier
Affiliation:
Vincent van Gogh Instituut voor Psychiatrie, Stationsweg 46, 5803 AC Venray
W.M.A. Verhoeven*
Affiliation:
Vincent van Gogh Instituut voor Psychiatrie, Stationsweg 46, 5803 AC Venray
*
Vincent van Gogh Instituut voor Psychiatrie, Stationsweg 46, 5803 AC Venray
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Summary

Since the introduction of international psychiatric classification systems, systematic diagnostic methods have become available for personality disorders. Recent developments in the dimensional diagnostic approach of personality disorders have yielded relationships between this type of disorders and neurobiological processes including both monoaminergic and stress-hormonal systems. It is hypothesized that the pathogenesis of borderline personality disorders is related to an enhanced serotonergic tone in septo-hippocampal structures. Preliminary clinical data are suggestive for potential therapeutic effects of serotonin-modulating compounds in borderline personality disorders

Keywords

Dimensional diagnosingborderline personality disordersserotonin-modulating compoundsstress-hormonesDimensionele diagnostiekborderline persoonlijkheidsstoornissenserotonine-modulerende farmacostresshormonen
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 7 , Issue 4 , December 1995 , pp. 127 - 131
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

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