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Pain perception in patients with bipolar disorder and schizophrenia

Published online by Cambridge University Press:  24 June 2014

Levent Atik ,
Numan Konuk ,
Omer Akay ,
Devrim Ozturk  and
Ayten Erdogan
Levent Atik
Affiliation:
Zon guldak Karaelmas University, Faculty of Medicine, Department of Psychiatry, Zonguldak, Turkey
Numan Konuk*
Affiliation:
Zon guldak Karaelmas University, Faculty of Medicine, Department of Psychiatry, Zonguldak, Turkey
Omer Akay
Affiliation:
Zon guldak Karaelmas University, Faculty of Medicine, Department of Psychiatry, Zonguldak, Turkey
Devrim Ozturk
Affiliation:
Zon guldak Karaelmas University, Faculty of Medicine, Department of Psychiatry, Zonguldak, Turkey
Ayten Erdogan
Affiliation:
Zon guldak Karaelmas University, Faculty of Medicine, Department of Psychiatry, Zonguldak, Turkey
*
Dr. Numan Konuk, Zonguldak Karaelmas Univerrsitesi, Týp fakultesi Psikiyatri, AD Kozlu Zonguldak, Zonguldak 67600, Turkey. Tel: +90 372 2610169; Fax: +90 372 2610155; E-mail: nkonuk@med.karaelmas.edu.tr
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Abstract

Objective:

Pain perception is reported to be altered in patients with depression and schizophrenia. However, few studies have investigated the pain perception in patients with bipolar disorders. We therefore aimed to compare pain sensitivity between patients with bipolar disorder, schizophrenia and controls.

Methods:

Study groups consisted of 30 patients with bipolar disorder, and control groups consisted of 27 patients with schizophrenia and 59 healthy subjects. Pain perception was assessed with cold pressor test (CPT) by exposure to ice-water.

Results:

Patients with schizophrenia had significantly higher pain thresholds (PTh) than patients with bipolar disorder. There were no differences between the PTh of patients with schizophrenia and healthy control subjects. However, patients with bipolar disorder had significantly lower pain tolerance (PT) in the CPT than patients with schizophrenia and corresponding healthy control subjects.

Conclusions:

The higher PTh in the schizophrenia group compared with the bipolar group found in this study supports further investigation of a potential difference in the pain perception between patients with schizophrenia and bipolar disorder. Theoretical implications of these findings and possible relevant behavioural and neurochemical mechanisms are discussed.

Keywords

bipolar disordercold pressor testpain sensitivityschizophrenia
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 19 , Issue 5 , October 2007 , pp. 284 - 290
Copyright
Copyright © 2007 Blackwell Munksgaard

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