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A case-control study of interleukin-12 1188A/C polymorphism in obsessive-compulsive disorder in Chinese population

Published online by Cambridge University Press:  24 June 2014

Shiguo Liu ,
Yanhui Liu ,
Yingying Yin ,
Xinhua Zhang  and
Xu Ma
Shiguo Liu
Affiliation:
Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China Institute of Clinical Research, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China Genetic Laboratory, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Yanhui Liu
Affiliation:
Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Yingying Yin
Affiliation:
Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Xinhua Zhang*
Affiliation:
Departments of psychiatry and Psychological clinic, The Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
Xu Ma*
Affiliation:
Graduate school, Peking Union Medical College, Beijing, China National Research Institute for Family Planning, Beijing, China World Health Organization Collaborating Centre for Research in Human Reproduction, Beijing, China
*
Xinhua Zhang, MD, Department of psychiatry, Medical College, Qingdao University, 16 Jiangsu Road, Qingdao 266003, China. Tel: +86 053282912012; Fax: +86 053282912016; E-mail: xhzhang87@126.com
Professor Xu Ma, Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing, 100081 China. Tel: +86 10 62176870; Fax: +86 10 62179151; E-mail: genetic@263.net.cn
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Extract

Objective: Previous studies indicated that the levels of serum interleukin (IL)-12 at baseline were elevated in obsessive-compulsive disorder (OCD) patients compared with control subjects, suggesting that IL-12 maybe involved in the etiopathogenesis of OCD. Therefore, we study the relationship between 1188A/C polymorphism of IL-12(rs3212227) and OCD in Chinese Han population.

Methods: We genotyped 194 OCD patients and 322 healthy individuals by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), then analyzed the data using case-control association test.

Results: No significant differences were found in 1188A/C genotypic and allelic frequencies between OCD cases and controls (X2 = 2.12, df = 2, P = 0.35 by genotype; X2 = 0.005, df = 1, P = 0.94 by allele).

Conclusions: Our results suggested that there may be lack of an association between OCD and IL-12 1188A/C polymorphism in Chinese Han population.

Keywords

interleukin-12obsessive-compulsive disorderpolymorphism
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 24 , Issue 3 , June 2012 , pp. 172 - 175
Copyright
Copyright © Cambridge University Press 2011

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References

1.Kessler, RC, Berglund, P, Demler, O, Jin, R, Merikangas, KR, Walters, EE.Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 2005;62:593–602.CrossRefGoogle ScholarPubMed
2.Bobes, J, Gonzalez, MP, Bascaran, MT, Arango, C, Saiz, PA, Bousono, M.Quality of life and disability in patients with obsessive–compulsive disorder. Eur Psychiatry 2001;16:239–245.CrossRefGoogle ScholarPubMed
3.Brambilla, F, Perna, G, Bellodi, L, et al. Decreased TNF-α and NK activity in obsessive-compulsive disorder. Psychoneuroendocrinology 2004;29:945–952.Google Scholar
4.Konuk, N, Tekin, IO, Ozturk, U et al. Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Mediators Inflamm 2007;2007: 65704.Google Scholar
5.Rovin, BH, Lu, L, Zhang, X.A novel interleukin-8 polymorphism is associated with severe systemic lupus erythematosus nephritis. Kidney Int 2002;62:261–265.Google Scholar
6.Gasche, C, Grundtner, P, Zwirn, P et al. Novel variants of the IL-10 receptor 1 affect inhibition of monocyte TNF-α production. J Immunol 2003;170:5578–5582.Google Scholar
7.Leckman, JF, Katsovich, L, Kawikova, I et al. Increased serum levels of interleukin-12 and tumor necrosis factor-alpha in Tourette's syndrome. Biol Psychiatry 2005;57:667–673.CrossRefGoogle ScholarPubMed
8.Church, AJ, Dale, RC, Cardoso, F et al. CSF and serum immune parameters in Sydenham's chorea: evidence of an autoimmune syndrome?. J Neuroimmunol 2003;136:149–153.Google Scholar
9.Morahan, G, Huang, D, Ymer, SI et al. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL-12B allele. Nat Genet 2001;27:218–221.CrossRefGoogle Scholar
10.Denys, D, Fluitman, S, Kavelaars, A, Heijnen, K, Westenberg, H.Decreased TNF-a and NK activity in obsessive–compulsive disorder. Psychoneuroendocrinology 2004;29:945–952.CrossRefGoogle Scholar
11.Huang, D, Cancilla, MR, Morahan, G.Complete primary structure, chromosomal localisation and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun 2000;1:515–520.Google Scholar
12.Sieburth, D, Jabs, EW, Warrington, JA et al. Assignment of genes encoding a unique cytokine (IL-12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 1992;14:59–62.Google Scholar
13.van Veen, T, Crusius, JB, Schrijver, HM et al. Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis. Ann Neurol 2001;50:275–279.Google Scholar
14.Seegers, D, Zwiers, A, Strober, W, Pena, AS, Bouma, G.A Taq1 polymorphism in the 3′UTR of the Il-12 p40 gene correlates with increased Il-12 secretion. Genes Immun 2002;3:419–423.Google Scholar
15.Arnold, PD, Rosenberg, DR, Mundo, E, Tharmalingam, S, Kennedy, JL, Richter, MA.Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl) 2004;174:530–538.Google Scholar
16.da Roch, FF, Correa, H, Teixeira, AL.Obsessive–compulsive disorder and immunology: a review. Biol Psychiatry 2008;32:1139–1146.Google Scholar
17.Stein, DJ.Obsessive–compulsive disorder. Lancet 2002;360:397–405.Google Scholar
18.Konuk, N, Tekin, IO, Ozturk, U et al. Plasma levels of tumor necrosis factor-alpha and interleukin-6 in obsessive compulsive disorder. Psychiatr Clin North Am 2006;29:445–469.Google Scholar
19.Monteleone, P, Catapano, F, Fabrazzo, M, Tortorella, A, Maj, M.Decreased blood levels of tumor necrosis factor-alpha in patients with obsessive-compulsive disorder. Neuropsychobiology 1998;37:182–185.Google Scholar
20.Carpenter, LL, Heninger, GR, McDougle, CJ, Tyrka, AR, Epperson, CN, Price, LH.Cerebrospinal fluid interleukin-6 in obsessive-compulsive disorder and trichotillomania. Psychiatry Res 2002;112:257–262.CrossRefGoogle ScholarPubMed
21.Kruager, GG, Langley, RG, Leonardi, C et al. A human interleukin-12/23 monoclonal antibody for the treatment of psoriasis [J]. N Engl J Med 2007;356:580–592.CrossRefGoogle Scholar
22.Rohowsky-koehan, C, Molinaro, D, Choudhry, A.Impaired interleukin-12 production in multiple sclerosis [J]. Mult Scler 1999;5:327–334.CrossRefGoogle Scholar
23.Neurath, MF.IL-23:a master regulator in Crohn disease [J]. Nat Med 2007;13:26–28.Google Scholar
24.Kuroda, S, Puri, P.Lack of association of IL8 gene polymorphisms with familial vesico-ureteral reflux. Pediatr Surg Int 2007;23:441–445.CrossRefGoogle ScholarPubMed