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Clozapine-induced palilalia?

Published online by Cambridge University Press:  24 June 2014

Jacinto C. Azevedo ,
Rui Lopes ,
Rosário Curral ,
Manuel F. Esteves ,
Rui Coelho  and
Antonio Roma-Torres
Jacinto C. Azevedo*
Affiliation:
Department of Psychiatry, Oporto Medical School, Porto, Portugal Department of Psychiatry, Hospital São João, Porto, Portugal
Rui Lopes
Affiliation:
Department of Psychiatry, Hospital São João, Porto, Portugal
Rosário Curral
Affiliation:
Department of Psychiatry, Oporto Medical School, Porto, Portugal Department of Psychiatry, Hospital São João, Porto, Portugal
Manuel F. Esteves
Affiliation:
Department of Psychiatry, Oporto Medical School, Porto, Portugal Department of Psychiatry, Hospital São João, Porto, Portugal
Rui Coelho
Affiliation:
Department of Psychiatry, Hospital São João, Porto, Portugal
Antonio Roma-Torres
Affiliation:
Department of Psychiatry, Oporto Medical School, Porto, Portugal
*
Jacinto C. Azevedo, Department of Psychiatry, Oporto Medical School, Al. Prof. Hernâni Monteiro 4200 - 319 Porto Portugal, Tel: +351 22 551 3600; Fax: +351 22 551 3601; E-mail: jacintoazevedo@gmail.com
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Extract

Introduction: Palilalia is an acquired speech disorder characterised by involuntary and spontaneous repetition of words or phrases two or more times in a row. It can occur in a variety of disorders including postencephalic parkinsonism, pseudobulbar palsy, schizophrenia, Gilles de la Tourette syndrome and others.

Clinical Case: We describe a case of a 28-year-old man with refractory schizophrenia that developed palilalia with 300 mg of clozapine. In the patient evaluation we found unspecific alterations in the electroencephalogram, with normal blood tests and cerebral magnetic resonance imaging. Palilalia disappeared with lowering doses of clozapine.

Discussion: The appearance of palilalia induced by clozapine is a rare pharmacologic side-effect which physicians should be familiarised with when evaluating this symptom presentation.

Keywords

antipsychoticclozapinepalilaliaschizophrenia
Type
Case Report
Information
Acta Neuropsychiatrica , Volume 24 , Issue 2 , April 2012 , pp. 122 - 124
Copyright
Copyright © Cambridge University Press 2011

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