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Dopamine D2/3 receptor availability and human cognitive impulsivity: a high-resolution positron emission tomography imaging study with [11C]raclopride

Published online by Cambridge University Press:  24 June 2013

Jong-Hoon Kim ,
Young-Don Son ,
Hang-Keun Kim ,
Sang-Yoon Lee ,
Young-Bo Kim  and
Zang-Hee Cho
Jong-Hoon Kim*
Affiliation:
Department of Psychiatry, Gil Medical Center, Gachon University, Namdong-Gu, Incheon, Korea
Young-Don Son
Affiliation:
Neuroscience Research Institute, Gachon University, Namdong-Gu, Incheon, Korea
Hang-Keun Kim
Affiliation:
Neuroscience Research Institute, Gachon University, Namdong-Gu, Incheon, Korea
Sang-Yoon Lee
Affiliation:
Neuroscience Research Institute, Gachon University, Namdong-Gu, Incheon, Korea
Young-Bo Kim
Affiliation:
Neuroscience Research Institute, Gachon University, Namdong-Gu, Incheon, Korea Department of Neurosurgery, Gil Medical Center, Gachon University, Namdong-Gu, Incheon, Korea
Zang-Hee Cho
Affiliation:
Neuroscience Research Institute, Gachon University, Namdong-Gu, Incheon, Korea
*
Jong-Hoon Kim, Department of Psychiatry, Gil Medical Center, Gachon University, Namdong-gu, Incheon, South Korea. Tel: +82 32 460 8505; Fax: +82 32 472 8813; E-mail: jhnp@chol.com
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Abstract

Objective

Human impulsivity is a complex multidimensional construct encompassing cognitive, emotional, and behavioural aspects. Previous animal studies have suggested that striatal dopamine receptors play a critical role in impulsivity. In this study, we investigated the relationship between self-reported impulsiveness and dopamine D2/3 receptor availability in striatal subdivisions in healthy subjects using high-resolution positron emission tomography (PET) with [11C]raclopride.

Methods

Twenty-one participants completed 3-T magnetic resonance imaging and high-resolution PET scans with [11C]raclopride. The trait of impulsiveness was measured using the Barratt Impulsiveness Scale (BIS-11). Partial correlation analysis was performed between BIS-11 scores and D2/3 receptor availability in striatal subregions, controlling for the confounding effects of temperament characteristics that are conceptually or empirically related to dopamine, which were measured by the Temperament and Character Inventory.

Results

The analysis revealed that the non-planning (p = 0.004) and attentional (p = 0.007) impulsiveness subscale scores on the BIS-11 had significant positive correlations with D2/3 receptor availability in the pre-commissural dorsal caudate. There was a tendency towards positive correlation between non-planning impulsiveness score and D2/3 receptor availability in the post-commissural caudate.

Conclusion

These results suggest that cognitive subtrait of impulsivity is associated with D2/3 receptor availability in the associative striatum that plays a critical role in cognitive processes involving attention to detail, judgement of alternative outcomes, and inhibitory control.

Keywords

dopamine receptorimpulsivitypositron emission tomographyraclopridestriatal subdivisions
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 26 , Issue 1 , February 2014 , pp. 35 - 42
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2013 

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