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Response of human melatonin secretion to changes in nightlength (scotoperiod): Implications for seasonal affective disorder and other psychiatric illnesses

Published online by Cambridge University Press:  18 September 2015

T.A. Wehr
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Extract

Many of the dramatic seasonal changes that occur in animals are triggered by changes in the length of night. Changes in the duration of melatonin secretion, which usually occurs exclusively at night and therefore lasts longer in winter than in summer, often act as a chemical transducer of the effects of seasonal changes in night-length on animals' behavior and physiology. Cells in sites that regulate seasonal behaviors, such as those associated with breeding, appear to possess melatonin receptors and interval timing mechanisms that enable them to detect melatonin and measure the duration of the nightly interval when it is present. These sites then trigger changes that are appropriate for the season that is indexed by the measured length of the interval.

Keywords

melatonincircadian rhythmseasonal affective disorderseasonsdepressiongendermelatoninecircadiaan ritmewinterdepressieseizoenendepressiegeslacht
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 7 , Issue 2 , June 1995 , pp. 35 - 37
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1995

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References

Literature

1.Pittendrigh, CS. The photoperiodic phenomena: Seasonal modulation of the “day within”. J biol Rhythms 1988; 3: 173–88.CrossRefGoogle ScholarPubMed
2.Bartness, TJ, Goldman, BD. Mammalian pineal melatonin: A clock for all seasons. Experientia Basel 1989; 45: 939–45.CrossRefGoogle ScholarPubMed
3.Wehr, TA. The durations of human melatonin secretion and sleep respond to changes in daylength (photoperiod). J clin Endocr Metab 1991; 73: 1276–80.CrossRefGoogle ScholarPubMed
4.Wehr, TA, Moul, DE, Giesen, HA, Seidel, JA, Barker, C, Bender, C. Conservation of photoperiod-responsive mechanisms in humans. Am J Physiol (Regulatory, Integrative and Comparative Physiology 34) 1993; 265: R846–57.Google ScholarPubMed
5.Wehr, TA, Giesen, HA, Moul, DE, Turner, EH, Schwartz, PJ. Suppression of men's responses to seasonal changes in daylength by modern artificial lighting. Am J Physiol (Regulatory, Integrative and Comparative Physiology), in press.Google Scholar
6.Rosenthal, NE, Jacobsen, FM, Sack, DA, Arendt, J, James, SP, Parry, BL, Wehr, TA. Atenolol in seasonal affective disorder: A test of the melatonin hypothesis. Am J Psychiat 1988; 145: 52–6.Google ScholarPubMed
7.Schlager, DS. Early morning administration of short-acting beta blockers for treatment of winter depression. Am J Psychiat 1994; 151: 1383–5.Google ScholarPubMed
8.Rosenthal, NE, Sack, DA, Jacobsen, FM, James, SP, Parry, BL, Arendt, J, Tamarkin, L, Wehr, TA, Melatonin in seasonal affective disorder and phototherapy. J neural Transm 1986; 21 (suppl): 257–67.Google ScholarPubMed
9.Wehr, TA, Jacobsen, FM, Sack, DA, Arendt, J, Tamarkin, L, Rosenthal, NE. Phototherapy of seasonal affective disorder: Time of day and suppression of melatonin are not critical for antidepressant effects. Arch gen Psychiat 1986; 43: 870–5.CrossRefGoogle Scholar