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Towards a new model for cellular pathophysiology in affective disorder

Published online by Cambridge University Press:  18 September 2015

C. Normann
C. Normann*
Affiliation:
Dept. of Psychiatry, University of Freiburg, Freiburg, Germany
*
Dept. of Psychiatry, University of Freiburg, Hauptstr. 5, 79104 Freiburg, GermanyTel 49-761-2706501, Fax 49-761-2706619, E-mail claus_normann@psyallg.ukl.uni-freiburg.de
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Abstract

The mode of action of serotonin in depression is unclear. We tested the modulation of hippocampal long-term plasticity, a model for learning and memory, by 5-HT and found a selective impairment of long-term depression resulting in a positive modification of synaptic network properties. We hypothetize a role for long-term plasticity in emotional regulation and the pathophysiology of affective disorders.

Keywords

serotoninlong-term plasticityaffective disorderselective serotonin reuptake inhibitors
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000 , pp. 77 - 80
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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References

1.Wilson, MA. McNaughton, BL. Dynamics of hippocampal ensemble code for space. Science 1993;261:1055–1058.CrossRefGoogle ScholarPubMed
2.O'Keefe, J. Reece, ML. Phase relationship between hippocampal place units ant the EEG theta rhvthm. Hippocampus 1993:3:317–330.CrossRefGoogle Scholar
3.Garlow, SJ, Musselmann, DL. Nemmeroff, CB. The neurochemistryof mood disorders: Clinical studies. In: Charney, DS, Nestler, EJ, Bunnev, BS (eds). Neurobiology of Mental Illnes. New York, Oxford University Press. 1999. pp 348–364.Google Scholar
4.Maes, M. Meltzer, HY. The serotonin hypothesis of mayor depression. In: Bloom, FE. Kupfer, DJ (eds). Psychopharmacology. the Fourth Generation of Progress. New York. Raven Press. 1995, pp 933–944.Google Scholar
5.Bliss, TVP. Lomo, T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforanl path. J Physiol 1973:232:331–356.CrossRefGoogle ScholarPubMed
6.Dudek, S. Bear, MF. Ilomosynaptic long-term depression in area CA1 of the hippocampus and effects of NMDA receptor blockade. PNAS 1992:89:4363–4367.CrossRefGoogle Scholar
7.Morris, RGM, Anderson, E. Lynch, GS. Baudry, M. Selective Impairment of learning and long-term potentiation by an NMDA antagonist. AP5. Nalure 1986:319:774–776Google Scholar
8.Bliss, TVP. Collingridge, GL. A synaptic model of memory: long-term potentiation in the hippocampus. Nature 1993:361:31–39.CrossRefGoogle ScholarPubMed
9.Markram, H. Lübke, J. Frotscher, M. Sakmann, B. Regulation of synaptic efficacy by coincidence of postsynaptic Aps and EPSPs. Science 1997:275:213–215.CrossRefGoogle ScholarPubMed
10.Xu, L. Anwyl, RRowan, MJ. Behavioural stress facilitates the induction of long-term depression in the hippocampus. Nature 1997:387:497–500.CrossRefGoogle ScholarPubMed
11.Maren, S. Long-term potentiation in the amygdala: a mechanism for emotional learning and memory. TINS 1999:22:561–567.Google ScholarPubMed