Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-10T16:44:10.422Z Has data issue: false hasContentIssue false
  • English
  • Français

Preferential Loss of Heterozygosity of Chromosome 7 Loci in Simian Virus 40 t/T Antigen-Induced Mouse Hepatocellular Carcinomas Does Not Involve H-ras Muatations

Published online by Cambridge University Press:  01 August 2014

S. Casola ,
M. Vernucci ,
P. Ungaro ,
C.B. Bruni  and
A. Riccio
S. Casola
Affiliation:
Center of Experimental Endocrinology and Oncology, CNR, Department of Molecular Cellular Biology and Pathology, University of Naples, Naples, Italy
M. Vernucci
Affiliation:
Center of Experimental Endocrinology and Oncology, CNR, Department of Molecular Cellular Biology and Pathology, University of Naples, Naples, Italy
P. Ungaro
Affiliation:
Center of Experimental Endocrinology and Oncology, CNR, Department of Molecular Cellular Biology and Pathology, University of Naples, Naples, Italy
C.B. Bruni
Affiliation:
Center of Experimental Endocrinology and Oncology, CNR, Department of Molecular Cellular Biology and Pathology, University of Naples, Naples, Italy
A. Riccio*
Affiliation:
Center of Experimental Endocrinology and Oncology, CNR, Department of Molecular Cellular Biology and Pathology, University of Naples, Naples, Italy
*
Centro di Endocrinologia ed Oncologia Sperimentale, CNR; Dipartimento di Biologia e Patologia Cellulare e Molecolare, Università di Napoli “Federico II”, via Pansini 5, 80131, Naples, Italy

Extract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Genetic complementation experiments have indicated that both a maternal and a paternal copy of the distal region of mouse chromosome 7 are essential for normal development [1]. This suggested the presence of genes whose expression is dependent on the gamete of origin in this chromosomal region. Two such imprinted genes, namely insulin-like growth factor II (Igf2) and H19, have been identified so far [2, 3]. The first encodes a peptide with mitotic activity towards several cell types, that contributes significantly to prenatal growth of mammals, whereas the second has, as yet, no defined role and seems not to encode any protein, but works as RNA. (Igf2) and H19 are located 90 kb apart, have similar expression patterns during development and are reciprocally imprinted, since the maternal Igf2 and the paternal H19 alleles are inactive in most fetal tissues [4, 5].

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 45 , Issue 1-2 , April 1996 , pp. 221 - 225
Copyright
Copyright © The International Society for Twin Studies 1996

References

REFERENCES

1. Searle, AG, Beechey, CV: Genomic imprinting phenomena on mouse chromosome 7. Genet Res 1990; 56: 237–244.Google Scholar
2. De Chiara, TM, Robertson, EJ, Efstratiadis, A: Parental imprinting of the mouse insulin-like growth factor II gene. Cell 1991; 64: 849–859.Google Scholar
3. Bartolomei, MS, Zemel, S, Tilghman, SM: Parental imprinting of the mouse H19 gene. Nature 1991; 351: 153–155.Google Scholar
4. Pfeiffer, K, Tilghman, SM: Allele-specific gene expression in mammals: The curious case of the imprinted RNAs. Genes Dev 1994; 8: 1867–1874.CrossRefGoogle Scholar
5. Zarrilli, R, Bruni, CB, Riccio, A: Multiple levels of control of insulin-like growth factor gene expression. Mol Cell Endocrinol 1994; 101: R1–R14.Google Scholar
6. Feinberg, AP: Genomic imprinting and gene activation in cancer. Nat Genet 1993; 4: 110–113.Google Scholar
7. Rainier, S, Johnson, LA, Dobry, CJ, Ping, AJ, Grundy, PE, Feinberg, AP: Relaxation of imprinted genes in human cancer. Nature 1993; 362: 747–749.Google Scholar
8. Ogawa, O, Eccles, MR, Szeto, J, McNoe, LA, Yun, K, Maw, MA, Smith, PJ, Reeve, A: Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature 1993; 362: 749–751.Google Scholar
9. Pedone, PV, Tirabosco, R, Cavazzana, AO, Ungaro, P, Basso, G, Luksch, R, Carli, M, Bruni, CB, Frunzio, R, Riccio, A: Mono and bi-allelic expression of insulin-like growth factor II gene in human muscle tumours. Hum Mol Genet 1994; 7: 1117–1121.Google Scholar
10. Suzulci, H, Ueda, R, Takahashi, T: Altered imprinting in lung cancer. Nat Genet 1994; 6: 332–333.Google Scholar
11. Steenman, MJ, Rainier, S, Dobry, CJ, Grundy, P, Horon, IL, Feinberg, AP: Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour. Nat Genet 1994; 7: 433–439.Google Scholar
12. Moulton, T, Crenshaw, T, Hao, Y, Moosikasuwan, J, Lin, N, Dembitzer, F, Hensle, T, Weiss, L, McMorrow, L, Loew, T, Kraus, W, Gerald, W, Tycko, B: Epigenetic lesions at the HI9 locus in Wilms' tumour patients. Nat Genet 1994; 7: 440–447.Google Scholar
13. Hao, Y, Crenshaw, T, Moulton, T, Newcomb, E, Tycko, B: Tumour-suppressor activity of H19 RNA. Nature 1993; 365: 764–767.CrossRefGoogle ScholarPubMed
14. Ruther, U, Woodroofe, C, Fattori, E, Ciliberto, G: Inducible formation of liver tumours in transgenic mice. Oncogene 1993; 8: 87–93.Google Scholar
15. Bianchi, AB, Navone, NM, Aldaz, CM, Conti, CJ: Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7Fl-ter in skin carcinogenesis. Proc Natl Acad Sci USA 1991; 88: 7590–7594.Google Scholar
16. Bremner, R, Baimain, A: Genetic changes in skin tumor progression: Correlation between presence of mutant ras gene and loss of heterozygosity on mouse chromosome 7. Cell 1990; 61: 407–417.CrossRefGoogle ScholarPubMed
17. Wiseman, R W, Stowers, SJ, Miller, EC, Anderson, MW, Miller, JA: Activating mutations of the c-Ha-ras protooncogene in chemically induced hepatomas of the male B6C3F1 mouse. Proc Natl Acad Sci USA 1986; 83: 5825–5829.Google Scholar
18. Buchmann, A, Bauer-Hofmann, R, Mahr, J, Drinkwater, NR, Luz, A, Schwarz, M: Mutational activation of the c-Ha-ras gene in liver tumours of different rodent strains: Correlation with susceptibility to hepatocarcinogenesis. 1991; 88: 911–915.Google Scholar
19. Baserga, R: Oncogenes and the strategy of growth factors. Cell 1994; 79: 927–930.Google Scholar
20. Pachnis, V, Belayew, A, Tilghman, SM: Locus unlinked to a-fetoprotein under the control of the murine raf and Rif genes. Proc Natl Acad Sci USA 1984; 81: 5523–5527.Google Scholar
21. Koi, M, Johnson, LA, Kalikin, LM, Little, PFR, Nakamura, Y, Feinberg, AP: Tumour cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. Science 1993; 260: 361–364.Google Scholar
22. Holdener, BC, Brown, SDM, Angel, JM, Nicholls, RD, Kelsey, G, Magnuson, T: Mouse chromosome 7. Mamm Genome 1993; 4: S110–S120.Google Scholar