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Effects of antibiotic resistance (AR) and microbiota shifts on Campylobacter jejuni-mediated diseases

Published online by Cambridge University Press:  18 April 2018

Phillip T. Brooks  and
Linda S. Mansfield
Phillip T. Brooks
Affiliation:
Comparative Enteric Diseases Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA Comparative Medicine and Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA Institute for Integrative Toxicology, Michigan State University, East Lansing, Michigan, USA
Linda S. Mansfield*
Affiliation:
Comparative Enteric Diseases Laboratory, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA Comparative Medicine and Integrative Biology, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan, USA
*
*Corresponding author. E-mail: mansfie4@cvm.msu.edu
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Abstract

Campylobacter jejuni is an important zoonotic pathogen recently designated a serious antimicrobial resistant (AR) threat. While most patients with C. jejuni experience hemorrhagic colitis, serious autoimmune conditions can follow including inflammatory bowel disease (IBD) and the acute neuropathy Guillain Barré Syndrome (GBS). This review examines inter-relationships among factors mediating C. jejuni diarrheal versus autoimmune disease especially AR C. jejuni and microbiome shifts. Because both susceptible and AR C. jejuni are acquired from animals or their products, we consider their role in harboring strains. Inter-relationships among factors mediating C. jejuni colonization, diarrheal and autoimmune disease include C. jejuni virulence factors and AR, the enteric microbiome, and host responses. Because AR C. jejuni have been suggested to affect the severity of disease, length of infections and propensity to develop GBS, it is important to understand how these interactions occur when strains are under selection by antimicrobials. More work is needed to elucidate host–pathogen interactions of AR C. jejuni compared with susceptible strains and how AR C. jejuni are maintained and evolve in animal reservoirs and the extent of transmission to humans. These knowledge gaps impair the development of effective strategies to prevent the emergence of AR C. jejuni in reservoir species and human populations.

Keywords

Campylobacter jejuniGuillain-Barré Syndromemicrobiomemouse modelsautoimmunityinflammationantibioticsantimicrobial resistance
Type
Review Article
Information
Animal Health Research Reviews , Volume 18 , Special Issue 2: Antimicrobial resistance: from basic science to translational innovation , December 2017 , pp. 99 - 111
Copyright
Copyright © Cambridge University Press 2018 

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