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Efficacy and safety of a feline immunodeficiency virus vaccine

Published online by Cambridge University Press:  28 February 2007

Chengjin Huang ,
Douglas Conlee ,
Jennifer Loop ,
Deborah Champ ,
Mike Gill  and
Hsien-Jue (Steve) Chu
Chengjin Huang*
Affiliation:
Fort Dodge Animal Health, 800 5th Street NW, Fort Dodge, IA 50501, USA
Douglas Conlee
Affiliation:
Fort Dodge Animal Health, 800 5th Street NW, Fort Dodge, IA 50501, USA
Jennifer Loop
Affiliation:
Fort Dodge Animal Health, 800 5th Street NW, Fort Dodge, IA 50501, USA
Deborah Champ
Affiliation:
Fort Dodge Animal Health, 800 5th Street NW, Fort Dodge, IA 50501, USA
Mike Gill
Affiliation:
Fort Dodge Animal Health, 800 5th Street NW, Fort Dodge, IA 50501, USA
Hsien-Jue (Steve) Chu
Affiliation:
Fort Dodge Animal Health, 800 5th Street NW, Fort Dodge, IA 50501, USA
*
*E-mail address: chuang@wyeth.com
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Abstract

Fel-O-Vax FIV is an inactivated virus vaccine designed as an aid in the prevention of infection of cats, 8 weeks or older, by feline immunodeficiency virus (FIV). It contains two genetically distinct FIV strains. The efficacy of this vaccine was demonstrated in a vaccination–challenge study designed to meet various regulatory requirements for registering the vaccine. Eight-week-old kittens were vaccinated with an immunogenicity vaccine which contained minimal release levels of FIV antigens formulated with a proprietary adjuvant system. Twelve months later, all vaccinates and controls were challenged with a heterologous FIV strain. Following the vigorous challenge exposure, cats were monitored for FIV viremia. It was found that 16% of the vaccinated cats developed viremia while 90% of the controls became persistently infected with FIV, which demonstrated that the vaccine was efficacious and the protective immunity lasted for at least 12 months. The safety of the vaccine was demonstrated by a field safety trial in which only 22 mild reactions of short duration were observed following administering 2051 doses of two pre-licensing serials of Fel-O-Vax FIV to cats of various breeds, ages and vaccination histories. Thus, Fel-O-Vax FIV is safe and efficacious for the prevention of FIV infection in cats.

Keywords

vaccinescatsfeline immunodeficiency virus
Type
Research Article
Information
Animal Health Research Reviews , Volume 5 , Issue 2 , December 2004 , pp. 295 - 300
Copyright
Copyright © CAB International 2004

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