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Phage-mediated dissemination of virulence factors in pathogenic bacteria facilitated by antibiotic growth promoters in animals: a perspective

Published online by Cambridge University Press:  29 November 2017

Migma Dorji Tamang ,
Hoon Sunwoo  and
Byeonghwa Jeon
Migma Dorji Tamang
Affiliation:
School of Public Health, University of Alberta, Edmonton, Alberta, Canada
Hoon Sunwoo
Affiliation:
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
Byeonghwa Jeon*
Affiliation:
School of Public Health, University of Alberta, Edmonton, Alberta, Canada
*
*Corresponding author. E-mail: bjeon@ualberta.ca
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Abstract

Addition of sub-therapeutic antibiotics to the feed of food-producing animals for growth promotion and disease prevention has become a common agricultural practice in many countries. The emergence of antibiotic-resistant pathogens is a looming concern associated with the use of antibiotic growth promoters (AGPs) around the world. In addition, some studies have shown that AGPs may not only affect antibiotic resistance but may also stimulate the dissemination of virulence factors via bacteriophages. Although only a few studies are currently available in the literature regarding this topic, in this article we endeavor to provide a perspective about how AGPs would impact the transmission of virulence factors by horizontal gene transfer via phages in a few pathogenic bacterial species significant to livestock production.

Keywords

antibiotic growth promotersbacteriophagesvirulence factorhorizontal gene transfer
Type
Review Article
Information
Animal Health Research Reviews , Volume 18 , Special Issue 2: Antimicrobial resistance: from basic science to translational innovation , December 2017 , pp. 160 - 166
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Copyright
Copyright © Cambridge University Press 2017 

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