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Effects of trace mineral amount and source on aspects of oxidative metabolism and responses to intramammary lipopolysaccharide challenge in midlactation dairy cows

Published online by Cambridge University Press:  16 October 2018

T. Yasui ,
R. M. Ehrhardt ,
G. R. Bowman ,
M. Vázquez-Añon ,
J. D. Richards ,
C. A. Atwell  and
T. R. Overton Open the ORCID record for T. R. Overton [Opens in a new window]
T. Yasui
Affiliation:
Department of Animal Science, Cornell University, Tower Road, Morrison Hall, 14853Ithaca, NY, USA
R. M. Ehrhardt
Affiliation:
Department of Animal Science, Cornell University, Tower Road, Morrison Hall, 14853Ithaca, NY, USA
G. R. Bowman
Affiliation:
Novus International, Inc., Research Park Drive, 63304Saint Charles, MO, USA
M. Vázquez-Añon
Affiliation:
Novus International, Inc., Research Park Drive, 63304Saint Charles, MO, USA
J. D. Richards
Affiliation:
Novus International, Inc., Research Park Drive, 63304Saint Charles, MO, USA
C. A. Atwell
Affiliation:
Novus International, Inc., Research Park Drive, 63304Saint Charles, MO, USA
T. R. Overton*
Affiliation:
Department of Animal Science, Cornell University, Tower Road, Morrison Hall, 14853Ithaca, NY, USA
*
†E-mail: tro2@cornell.edu
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Abstract

Trace minerals have important roles in immune function and oxidative metabolism; however, little is known about the relationships between supplementation level and source with outcomes in dairy cattle. Multiparous Holstein cows (n=48) beginning at 60 to 140 days in milk were utilized to determine the effects of trace mineral amount and source on aspects of oxidative metabolism and responses to intramammary lipopolysaccharide (LPS) challenge. Cows were fed a basal diet meeting National Research Council (NRC) requirements except for no added zinc (Zn), copper (Cu) or manganese (Mn). After a 4-week preliminary period, cows were assigned to one of four topdress treatments in a randomized complete block design with a 2×2 factorial arrangement of treatments: (1) NRC inorganic (NRC levels using inorganic (sulfate-based) trace mineral supplements only); (2) NRC organic (NRC levels using organic trace mineral supplements (metals chelated to 2-hydroxy-4-(methythio)-butanoic acid); (3) commercial inorganic (approximately 2×NRC levels using inorganic trace mineral supplements only; and (4) commercial organic (commercial levels using organic trace mineral supplements only). Cows were fed the respective mineral treatments for 6 weeks. Treatment effects were level, source and their interaction. Activities of super oxide dismutase and glutathione peroxidase in erythrocyte lysate and concentrations of thiobarbituric acid reactive substances (TBARS) and total antioxidant capacity (TAC) in plasma were measured as indices of oxidative metabolism. Effects of treatment on those indices were not significant when evaluated across the entire experimental period. Plasma immunoglobulin G level was higher in cows supplemented with organic trace minerals over the entire treatment period; responses assessed as differences of before and after Escherichia coli J5 bacterin vaccination at the end of week 2 of treatment period were not significant. Cows were administered an intramammary LPS challenge during week 5; during week 6 cows fed commercial levels of Zn, Cu and Mn tended to have higher plasma TAC and cows fed organic sources had decreased plasma TBARS. After the LPS challenge, the extent and pattern of response of plasma cortisol concentrations and clinical indices (rectal temperature and heart rate) were not affected by trace mineral level and source. Productive performance including dry matter intake and milk yield and composition were not affected by treatment. Overall, results suggest that the varying level and source of dietary trace minerals do not have significant short-term effects on oxidative metabolism indices and clinical responses to intramammary LPS challenge in midlactation cows.

Keywords

dairy cattlecopperzincmanganeseoxidative metabolism
Type
Research Article
Information
animal , Volume 13 , Issue 5 , May 2019 , pp. 1000 - 1008
Copyright
© The Animal Consortium 2018 

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References

Aitken, SL , Karcher, EL , Rezamand, P , Gandy, JC , VandeHaar, MJ , Capuco, AV and Sordillo, LM 2009. Evaluation of antioxidant and proinflammatory gene expression in bovine mammary tissue during the periparturient period. Journal of Dairy Science 92, 589–598.Google Scholar
Allison, RD and Laven, RA 2000. Effect of vitamin E supplementation on the health and fertility of dairy cows: a review. Veterinary Record 147, 703–708.Google Scholar
Association of Official Analytical Chemists (AOAC) 2000. Official methods of analysis, 17th edition. AOAC, Arlington, VA, USA.Google Scholar
Bengoumi, M , Essamadi, K , Charcornac, JP , Tressol, JC and Faye, B 1998. Comparative relationship between copper-zinc plasma concentrations and superoxide dismutase activity in camels and cows. Veterinary Research 29, 557–565.Google Scholar
Bernabucci, U , Ronchi, B , Lacetera, N and Nardone, A 2005. Influence of body condition score on relationships between metabolic status and oxidative stress in periparturient dairy cows. Journal of Dairy Science 88, 2017–2026.Google Scholar
Bremner, I , Humphries, WR , Phillippo, M , Walker, MJ and Morrice, PC 1987. Iron-induced copper deficiency in calves: dose-response relationships and interactions with molybdenum and sulphur. Animal Production 45, 403–414.Google Scholar
Celi, P 2011. Biomarkers of oxidative stress in ruminant medicine. Immunopharmacology and Immunotoxicology 33, 233–240.Google Scholar
Failla, ML 2003. Trace elements and host defense: recent advances and continuing challenges. Journal of Nutrition 133, 1443S–1447S.Google Scholar
Kaygusuzoglu, E 2012. Levels of vitamin A, C, E with malondialdehyde in blood and milk serum in subclinical mastitic cows. Journal of Animal and Veterinary Advances 11, 2284–2288.Google Scholar
Lykkesfeldt, J and Svendsen, O 2007. Oxidants and antioxidants in disease: oxidative stress in farm animals. The Veterinary Journal 173, 502–511.Google Scholar
Miller, JK , Brzezinska-Slebodzinska, E and Madsen, FC 1993. Oxidative stress, antioxidants, and animal function. Journal of Dairy Science 76, 2812–2823.Google Scholar
Nemec, LM , Hidiroglou, M , Nielsen, K and Proulx, J 1990. Effect of vitamin E and selenium supplementation on some immune parameters following vaccination against brucellosis in cattle. Journal of Animal Science 68, 4303–4309.Google Scholar
Nemec, LM , Richards, JD , Atwell, CA , Diaz, DE , Zanton, GI and Gressley, TF 2012. Immune responses in lactating Holstein cows supplemented with Cu, Mn, and Zn as sulfates or methionine hydroxy analogue chelates. Journal of Dairy Science 95, 4568–4577.Google Scholar
National Research Council (NRC) 2001. Nutrient requirements of dairy cattle, 7th revised edition. National Academy Press, Washington, DC, USA.Google Scholar
Phillippo, M , Humphries, WR and Garthwaite, PH 1987. The effect of dietary molybdenum and iron on copper status and growth in cattle. The Journal of Agricultural Science 109, 315–320.Google Scholar
Ranjan, R 2005. Enhanced erythrocytic lipid peroxides and reduced plasma ascorbic acid, and alteration in blood trace elements level in dairy cows with mastitis. Veterinary Research Communications 29, 27–34.Google Scholar
Sies, H 1991. Oxidative Stress: oxidants and antioxidants. Elsevier Science Publishing, San Diego, CA, USA.Google Scholar
Sirois, PK , Reuter, MJ , Laughlin, CM and Lockwood, PJ 1994. A method for determining macro and micro elements in forages and feeds by inductively coupled plasma atomic emission spectrometry. The Spectroscopist 3, 6–9.Google Scholar
Sordillo, LM and Aitken, SL 2009. Impact of oxidative stress on the health and immune function of dairy cattle. Veterinary Immunology and Immunopathology 128, 104–109.Google Scholar
Sordillo, LM , O’Boyle, N , Gandy, JC , Corl, CM and Hamilton, E 2007. Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle. Journal of Dairy Science 90, 1186–1192.Google Scholar
Spears, JW and Weiss, WP 2008. Role of antioxidants and trace elements in health and immunity of transition dairy cows. The Veterinary Journal 176, 70–76.Google Scholar
Tanaka, M , Kamiya, Y , Suzuki, T and Nakai, Y 2011. Changes in oxidative status in periparturient dairy cows in hot conditions. Animal Science Journal 82, 320–324.Google Scholar
Valko, M , Leibfritz, D , Moncol, J , Cronin, MT , Mazur, M and Telser, J 2007. Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry and Cell Biology 39, 44–84.Google Scholar
Van Soest, PJ , Robertson, JB and Lewis, BA 1991. Methods for dietary fiber, neutral detergent fiber, and nonstarch polysaccharides in relation to animal nutrition. Journal of Dairy Science 74, 3583–3597.Google Scholar
Waldron, MR , Kulick, AE , Bell, AW and Overton, TR 2006. Acute experimental mastitis is not causal toward the development of energy-related metabolic disorders in early postpartum dairy cows. Journal of Dairy Science 89, 596–610.Google Scholar
Wildman, EE , Jones, GM , Wagner, PE , Boman, RL , Troutt, HF Jr and Lesch, TN 1982. A dairy cow body condition scoring system and its relationship to selected production characteristics. Journal of Dairy Science 65, 495–501.Google Scholar
Zhao, XJ , Li, ZP , Wang, JH , Xing, XM , Wang, ZY , Wang, L and Wang, ZH 2015. Effects of chelated Zn/Cu/Mn on redox status, immune responses and hoof health in lactating Holstein cows. Journal of Veterinary Science 16, 439–446.Google Scholar