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Recoverin and Ca2+ in vertebrate phototransduction

Published online by Cambridge University Press:  04 February 2010

James B. Hurley
James B. Hurley*
Affiliation:
Department of Biochemistry and Howard Hughes Medical Institute, SL-15 University of Washington, Seattle, WA 98195 Electronic mail: jbhhh@u.washington.edu
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Abstract

Recoverin is a 23 kDa Ca2+binding protein that has been detected primarily in vertebrate photoreceptors. The role of recoverin in phototransduction has been investigated using a variety of biochemical methods. Initial reports suggesting that recoverin regulates photoreceptor guanylyl cyclase have not been confirmed. Instead, recoverin appears to determine the lifetime of lightstimulated phosphodiesterase activity, perhaps by regulating rhodopsin phosphorylation. Retinal recoverin is heterogeneously fatty acylated at its ammo-terminus. The amino-terminal fatty acid appears to be involved in the interaction of recoverin with photoreceptor membranes.

Keywords

cyclic CMPguanylyl cyclasephosphodiesterasephosphorylationphototransductionrecoverinretinarhodopsinkinase
Type
Research Article
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 425 - 428
Copyright
Copyright © Cambridge University Press 1995

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