The requirements of a major biological hypothesis

Abstract

Abundant pathophysiological and clinical evidence suggests that the algogenic code responsible for cardiac pain is not based on “specific” mechanisms (mcmahon). Recent evidence, however, has led various authors to postulate that some degree of specificity might be involved in visceral pain arising from other sources, but a “spatio-temporal” intensity pattern is still the most plausible hypothesis for the genesis of visceral pain.