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Are fetal brain tissue grafts necessary for the treatment of brain damage?

Published online by Cambridge University Press:  04 February 2010

Donald G. Stein  and
Marylou M. Glasier
Donald G. Stein
Affiliation:
Laboratory of Brain Research and CNS Plasticity Institute of Animal Behavior, Rutgers University Newark, NJ 07102. steln@draco.rutgers.edu
Marylou M. Glasier
Affiliation:
Laboratory of Brain Research and CNS Plasticity Institute of Animal Behavior, Rutgers University Newark, NJ 07102. steln@draco.rutgers.edu
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Abstract

Despite some clinical promise, using fetal transplants for degenerative and traumatic brain injury remains controversial and a number of issues need further attention. This response reexamines a number of questions. Issues addressed include: temporal factors relating to neural grafting, the role of behavioral experience in graft outcome, and the relationship of rebuilding of neural circuitry to functional recovery. Also discussed are organization and type of transplanted tissue, the “trophic hypothesis” of transplant viability, and whether transplants are really needed to obtain functional recovery after brain damage.

Type
Authors' Responses
Information
Behavioral and Brain Sciences , Volume 18 , Issue 1: An International Journal of Current Research and Theory with Open Peer Commentary , March 1995 , pp. 86 - 107
Copyright
Copyright © Cambridge University Press 1995

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