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Imagery-Focused Cognitive Therapy (ImCT) for Mood Instability and Anxiety in a Small Sample of Patients with Bipolar Disorder: a Pilot Clinical Audit

Published online by Cambridge University Press:  09 July 2018

Susie A. Hales*
Affiliation:
Oxford Institute of Clinical Psychology Training, Oxford, UK
Martina Di Simplicio
Affiliation:
Centre for Psychiatry, Brain Sciences Division, Imperial College London, London, UK MRC Cognition and Brain Sciences Unit, Cambridge, UK
Lalitha Iyadurai
Affiliation:
Department of Psychiatry, University of Oxford and Oxford Health NHS Foundation Trust, UK
Simon E. Blackwell
Affiliation:
Ruhr Universität-Bochum, Bochum, Germany
Kerry Young
Affiliation:
Central and North West London NHS Foundation Trust, UK
Christopher G. Fairburn
Affiliation:
Department of Psychiatry, University of Oxford and Oxford Health NHS Foundation Trust, UK
John R. Geddes
Affiliation:
Department of Psychiatry, University of Oxford; NIHR Oxford Health Biomedical Research Centre and Oxford Health NHS Foundation Trust, UK
Guy M. Goodwin
Affiliation:
Department of Psychiatry, University of Oxford and Oxford Health NHS Foundation Trust, UK
Emily A. Holmes
Affiliation:
Division of Psychology, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
*
Correspondence to Susie A. Hales, Oxford Institute of Clinical Psychology Training, Oxford, UK. E-mail: susie.hales@hmc.ox.ac.uk

Abstract

Background: Despite the global impact of bipolar disorder (BD), treatment success is limited. Challenges include syndromal and subsyndromal mood instability, comorbid anxiety, and uncertainty around mechanisms to target. The Oxford Mood Action Psychology Programme (OxMAPP) offered a novel approach within a cognitive behavioural framework, via mental imagery-focused cognitive therapy (ImCT). Aims: This clinical audit evaluated referral rates, clinical outcomes and patient satisfaction with the OxMAPP service. Method: Eleven outpatients with BD received ImCT in addition to standard psychiatric care. Mood data were collected weekly from 6 months pre-treatment to 6 months post-treatment via routine mood monitoring. Anxiety was measured weekly from start of treatment until 1 month post-treatment. Patient feedback was provided via questionnaire. Results: Referral and treatment uptake rates indicated acceptability to referrers and patients. From pre- to post-treatment, there was (i) a significant reduction in the duration of depressive episode relapses, and (ii) a non-significant trend towards a reduction in the number of episodes, with small to medium effect size. There was a large effect size for the reduction in weekly anxiety symptoms from assessment to 1 month follow-up. Patient feedback indicated high levels of satisfaction with ImCT, and underscored the importance of the mental imagery focus. Conclusions: This clinical audit provides preliminary evidence that ImCT can help improve depressive and anxiety symptoms in BD as part of integrated clinical care, with high patient satisfaction and acceptability. Formal assessment designs are needed to further test the feasibility and efficacy of the new ImCT treatment on anxiety and mood instability.

Type
Research Article
Copyright
Copyright © British Association for Behavioural and Cognitive Psychotherapies 2018 

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References

Alda, M. (2015). Lithium in the treatment of bipolar disorder: pharmacology and pharmacogenetics. Molecular Psychiatry, 20, 661670. doi: 10.1038/mp.2015.4Google Scholar
Altman, E. G., Hedeker, D., Peterson, J. L. and Davis, J. M. (1997). The Altman self-rating mania scale. Biological Psychiatry, 42, 948955. doi: https://doi.org/10.1016/S0006-3223(96)00548-3Google Scholar
American Psychiatric Association (2000). Diagnostic and Statistical Manual of Mental Disorders, text revision (4th edn). Washington DC: American Psychiatric Association.Google Scholar
American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (5th edn). Arlington, VA: American Psychiatric Publishing.Google Scholar
Arntz, A., Tiesema, M. and Kindt, M. (2007). Treatment of PTSD: a comparison of imaginal exposure with and without imagery rescripting. Journal of Behavior Therapy and Experimental Psychiatry, 38, 345370.Google Scholar
Beck, A. T. and Steer, R. A. (1993). Beck Anxiety Inventory Manual. San Antonio: Psychological Corporation.Google Scholar
Bilderbeck, A. C., Reed, Z. E., McMahon, H. C., Atkinson, L. Z., Price, J., Geddes, J. R. et al. (2016). Associations between mood instability and emotional processing in a large cohort of bipolar patients. Psychological Medicine, 46, 31513160.Google Scholar
Bonsall, M. B., Geddes, J. R., Goodwin, G. M. and Holmes, E. A. (2015). Bipolar disorder dynamics: affective instabilities, relaxation oscillations and noise. Journal of the Royal Society Interface, 12, 111. doi: 10.1098/rsif.2015.0670Google Scholar
Brewin, C. R., Wheatley, J., Patel, T., Fearon, P., Hackmann, A., Wells, A. et al. (2009). Imagery rescripting as a brief stand-alone treatment for depressed patients with intrusive memories. Behaviour Research and Therapy, 47, 569576.Google Scholar
British Psychological Society (BPS) Division of Clinical Psychology. (2015). Guidelines on language in relation to functional psychiatric diagnosis (pp. 16). Leicester: The British Psychological Society.Google Scholar
British Psychological Society (BPS) Professional Practice Board (2008). Generic professional practice guidelines. Leicester: The British Psychological Society.Google Scholar
Clark, D. M. and Wells, A. (1995). A cognitive model of social phobia. In Heimberg, R. G., Liebowitz, M., Hope, D. and Schneier, F. (eds), Social Phobia: Diagnosis, Assessment and Treatment (pp. 6993). New York: Guilford Press.Google Scholar
Di Simplicio, M., Renner, F., Blackwell, S. B., Mitchell, H., Stratford, H. J., Watson, P. et al. (2016). An investigation of mental imagery in bipolar disorder: exploring ‘the mind's eye’. Bipolar Disorders, 18, 669683. doi: 10.1111/bdi.12453Google Scholar
Everitt, B. S. and Dunn, G. (1991). Applied Multivariate Data Analysis. London: Edward Arnold.Google Scholar
Frank, E., Swartz, H. A. and Boland, E. (2007). Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder. Dialogues in Clinical Neuroscience, 9, 325332. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202498/Google Scholar
Frank, E., Swartz, H. A. and Kupfer, D. J. (2000). Interpersonal and social rhythm therapy: managing the chaos of bipolar disorder. Biological Psychiatry, 48, 593604.Google Scholar
Geddes, J. R. and Miklowitz, D. J. (2013). Treatment of bipolar disorder. Lancet, 381, 16721682. doi: 10.1016/S0140-6736(13)60857-0Google Scholar
Goodwin, G. M. (2016). Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology, 30, 495553. doi: 10.1177/0269881116636545Google Scholar
Hales, S. A., Blackwell, S. E., Di Simplicio, M., Iyadurai, L., Young, K. and Holmes, E. A. (2015). Imagery-based cognitive assessment. In Brown, G. P. and Clark, D. A. (eds), Cognitive Behavioural Assessment, Diagnosis and Case Formulation. New York: Guilford Press.Google Scholar
Hales, S. A., Deeprose, C., Goodwin, G. M. and Holmes, E. A. (2011). Cognitions in bipolar disorder versus unipolar depression: imagining suicide. Bipolar Disorders, 13, 651661. doi: 10.1111/j.1399-5618.2011.00954.xGoogle Scholar
Hawton, K., Sutton, L., Haw, C., Sinclair, J. and Harriss, L. (2005). Suicide and attempted suicide in bipolar disorder: a systematic review of risk factors. Journal of Clinical Psychiatry, 66, 693704. doi: 10.4088/JCP.v66n0604Google Scholar
Hirsch, C. R. and Holmes, E. A. (2007). Mental imagery in anxiety disorders. Psychiatry, 6, 161165. doi: 10.1016/j.mppsy.2007.01.005Google Scholar
Holmes, E. A., Arntz, A. and Smucker, M. R. (2007). Imagery rescripting in cognitive behaviour therapy: images, treatment techniques and outcomes. Journal of Behavior Therapy and Experimental Psychiatry, 38, 297305. doi: 10.1016/j.jbtep.2007.10.007Google Scholar
Holmes, E. A., Bonsall, M. B., Hales, S. A., Mitchell, H., Renner, F., Blackwell, S. E. et al. (2016). Applications of time-series analysis to mood fluctuations in bipolar disorder to promote treatment innovation: a case series. Translational Psychiatry, 6, e720. doi: 10.1038/tp.2015.207Google Scholar
Holmes, E. A., Deeprose, C., Fairburn, C. G., Wallace-Hadrill, S. M. A., Bonsall, M. B., Geddes, J. R. and Goodwin, G. M. (2011). Mood stability versus mood instability in bipolar disorder: a possible role for emotional mental imagery. Behaviour Research and Therapy, 49, 707713. doi: 10.1016/j.brat.2011.06.008Google Scholar
Holmes, E. A., Geddes, J. R., Colom, F. and Goodwin, G. M. (2008). Mental imagery as an emotional amplifier: application to bipolar disorder. Behaviour Research and Therapy, 46, 12511258. doi: 10.1016/j.brat.2008.09.005.Google Scholar
Holmes, E. A., Hales, S. A., Di Simplicio, M. and Young, K. A. D. (in press). Imagery in CBT: a workbook for bipolar disorder and beyond. New York: Guilford Press.Google Scholar
Jauhar, S., McKenna, P. J. and Laws, K. R. (2016). NICE guidance on psychological treatments for bipolar disorder: searcing for the evidence. Lancet Psychiatry, 3, 386388. doi: https://doi.org/10.1016/S2215-0366(15)00545-3Google Scholar
Jones, S. H., McGrath, E., Hampshire, K., Owen, R., Riste, L., Roberts, C. et al. (2013). A randomised controlled trial of time limited CBT informed psychological therapy for anxiety in bipolar disorder. BMC Psychiatry, 13, 18. doi: 10.1186/1471-244X-13-54Google Scholar
Jones, S. H., Smith, G., Mulligan, L. D., Lobban, F., Law, H., Dunn, G. et al. (2015). Recovery-focused cognitive–behavioural therapy for recent-onset bipolar disorder: randomised controlled pilot trial. British Journal of Psychiatry, 206, 5866. doi: 10.1192/bjp.bp.113.141259Google Scholar
Judd, L. L., Akiskal, H. S., Schetteler, P. J., Endicott, J., Maser, J., Solomon, D. A. et al. (2002). The long-term natural history of the weekly symptomatic status of bipolar I disorder. Archives of General Psychiatry, 59, 530537.Google Scholar
Lam, D. H., Hayward, P., Watkins, E. R., Wright, K. and Sham, P. (2005). Relapse prevention in patients with bipolar disorder: cognitive therapy outcome after 2 years. American Journal of Psychiatry, 162, 324329. doi: 10.1176/appi.ajp.162.2.324Google Scholar
Lam, D. H., Watkins, E. R., Hayward, P., Bright, J., Wright, K., Kerr, N. et al. (2003). A randomized controlled study of cognitive therapy for relapse prevention for bipolar affective disorder: outcome of the first year. Archives of General Psychiatry, 60, 145152. doi: 10.1001/archpsyc.60.2.145Google Scholar
Malik, A., Goodwin, G. M. and Holmes, E. A. (2012). Contemporary approaches to frequent mood monitoring in bipolar disorder. Journal of Experimental Psychopathology, 3, 572581. doi: 10.5127/jep.014311Google Scholar
Malik, A., Goodwin, G. M., Hoppitt, L. and Holmes, E. A. (2014). Hypomanic experience in young adults confers vulnerability to intrusive imagery after experimental trauma: relevance for bipolar disorder. Clinical Psychological Science, 2, 675684. doi: 10.1177/2167702614527433Google Scholar
Mansell, W. and Pedley, R. (2008). The ascent into mania: a review of psychological processes associated with the development of manic symptoms. Clinical Psychology Review, 28, 494520. doi: 10.1016/j.cpr.2007.07.010Google Scholar
Mansell, W., Tai, S., Clark, A., Akgonul, S., Dunn, G., Davies, L. et al. (2014). A novel cognitive behaviour therapy for bipolar disorders (Think Effectively About Mood Swings or TEAMS): study protocol for a randomized controlled trial. Trials, 15. doi: 10.1186/1745-6215-15-405Google Scholar
Marangell, L. B., Dennehy, E. B., Miyahara, S., Wisniewski, S. R., Bauer, M. S., Rapaport, M. H. and Allen, M. H. (2009). The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD. Journal of Affective Disorders, 114, 5867. doi: 10.1016/j.jad.2008.07.006Google Scholar
Merikangas, K. R., Akiskal, H. S., Angst, J., Greenberg, P. E., Hirschfeld, R. M., Petukhova, M. and Kessler, R. C. (2007). Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbity Survey replication. Archives of General Psychiatry, 64, 543552. doi: 10.1001/archpsyc.64.5.543Google Scholar
Miklowitz, D. J., Price, J., Holmes, E. A., Rendell, J., Bell, S., Budge, K. et al. (2012). Facilitated Integrated Mood Management for adults with bipolar disorder. Bipolar Disorders, 14, 185197. doi: 10.1111/j.1399-5618.2012.00998.x.Google Scholar
Miura, T., Noma, H., Furukawa, T. A., Mitsuyasu, H., Tanaka, S., Stockton, S. et al. (2014). Comparative efficacy and tolerability of pharmacological treatments in the maintenance treatment of bipolar disorder: a systematic review and network meta-analysis. Lancet Psychiatry, 4, 351359. doi: 10.1016/S2215-0366(14)70314-1Google Scholar
National Institute for Health and Care Excellence (NICE) (2014). National Clinical Guidance 185: Bipolar disorder: the assessment and management of bipolar disorder in adults, children, and young people in primary and secondary care.Google Scholar
Ng, R. M. K., Burnett Heyes, S., McManus, F., Kennerley, H. and Holmes, E. A. (2016a). Bipolar risk and mental imagery susceptibility in a representative sample of Chinese adults residing in the community. International Journal of Social Psychiatry, 62, 94102. doi: 10.1177/0020764015597951Google Scholar
Ng, R. M. K., Di Simplicio, M. and Holmes, E. A. (2016b). Mental imagery and bipolar disorders: introducing scope for psychological treatment development? [Editorial]. International Journal of Social Psychiatry, 62, 100113. doi: 10.1177/0020764015615905Google Scholar
O'Garro-Moore, J. K., Adams, A. M., Abramson, L. Y. and Alloy, L. B. (2015). Anxiety comorbidity in bipolar spectrum disorders: the mediational role of perfectionism in prospective depressive symptoms. Journal of Affective Disorders, 174, 180187. doi: 10.1016/j.jad.2014.11.024Google Scholar
O'Donnell, C., Di Simplicio, M., Brown, R., Holmes, E. A. and Burnett Heyes, S. (2017). Mental imagery and its amplification of mood: an investigation across a spectrum of hypomanic-like experiences. Cortex, pii: S0010-9452(0017)30265-30264. doi: https://doi.org/10.1016/j.cortex.2017.08.010Google Scholar
Otto, M. W., Simon, N. M., Wisniewski, S. R., Miklowitz, D. J., Kogan, J. N., Reilly-Harrington, N. A. et al. (2006). Prospective 12-month course of bipolar disorder in out-patients with and without comorbid anxiety disorders. British Journal of Psychiatry, 189, 2025. doi: 10.1192/bjp.bp.104.007773Google Scholar
Oud, M., Mayo-Wilson, E., Braidwood, R., Schulte, P., Jones, S. H., Morriss, R. et al. (2016). Psychological interventions for adults with bipolar disorder: systematic review and meta-analysis. British Journal of Psychiatry, 208, 213222. doi: 10.1192/bjp.bp.114.157123Google Scholar
Oxford Health National Health Service (NHS) Foundation Trust (2013). Clinical Audit/Quality Improvement Proposal: Service evaluation of clinical psychology input for bipolar disorder within the Mood Disorders Clinic (updated 11 April 2013).Google Scholar
Palmier-Claus, J. E., Dodd, A., Tai, S., Emsley, R. and Mansell, W. (2016). Appraisals to affect: testing the integrative cognitive model of bipolar disorder. British Journal of Clinical Psychology, 55, 225235. doi: 10.1111/bjc.12081Google Scholar
Patel, T., Brewin, C. R., Wheatley, J., Wells, A., Fisher, P. and Myers, S. (2007). Intrusive images and memories in major depression. Behaviour research and therapy, 45 (11), 25732580. doi: 10.1016/0005-7967(94)90140-6Google Scholar
Pearson, J., Naselaris, T., Holmes, E. A. and Kosslyn, S. M. (2015). Mental imagery: functional mechanisms and clinical applications. Trends in Cognitive Sciences, 19, 590602. doi: 10.1016/j.tics.2015.08.003Google Scholar
Rush, J. A., Trivedi, M. H., Ibrahim, H. M., Carmody, T. J., Arnow, B., Klein, D. N. et al. (2003). The 16-item quick inventory of depressive symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression. Biological Psychiatry, 54, 573583. doi: 10.1016/S0006-3223(02)01866-8Google Scholar
Scott, J. and Colom, F. (2008). Gaps and limitations of psychological interventions for bipolar disorders. Psychotherapy and Psychosomatics, 22, 411.Google Scholar
Scott, J., Paykel, E. S., Morriss, R., Kinderman, P., Johnson, T., Abbott, R. and Hayhurst, H. (2006). Cognitive-behavioural therapy for severe and recurrent bipolar disorders: randomised controlled trial. British Journal of Psychiatry, 188, 313320. doi: 10.1192/bjp.188.4.313Google Scholar
Searson, R., Mansell, W., Lowens, I. and Tai, S. (2012). Think Effectively About Mood Swings (TEAMS): a case series of cognitive-behavioural therapy for bipolar disorders. Journal of Behavior Therapy and Experimental Psychiatry, 43, 770779.Google Scholar
Severus, E., Taylor, M. J., Sauer, C., Pfennig, A., Ritter, P., Bauer, M. and Geddes, J. R. (2014). Lithium for prevention of mood episodes in bipolar disorders: systematic review and meta-analysis. International Journal of Bipolar Disorders, 2, 117. doi: 10.1186/s40345-014-0015-8Google Scholar
Simon, G. E., Hunkeler, E., Fireman, B., Lee, J. Y. and Savarino, J. (2007). Risk of suicide attempt and suicide death in patients treated for bipolar disorder. Bipolar Disorders, 9, 526530.Google Scholar
Stratford, H., Blackwell, S. E., Di Simplicio, M., Cooper, M. and Holmes, E. A. (2015). Psychological therapy for anxiety in bipolar spectrum disorders: a systematic review. Clinical Psychological Review, 35, 1934. doi: 10.1016/j.cpr.2014.11.002Google Scholar
Strejilevich, S. A., Martino, D. J., Murru, A., Teitelbaum, J., Fassi, G., Marengo, E. et al. (2013). Mood instability and functional recovery in bipolar disorders. Acta Psychiatrica Scandinavica, 128, 194202. doi: 10.1111/acps.12065Google Scholar
Szentagotai, A. and David, D. (2010). The efficacy of cognitive-behavioral therapy in bipolar disorder: a quantitative meta-analysis. Journal of Clinical Psychiatry, 71, 6672.Google Scholar
Vallarino, M., Henry, C., Etain, B., Gehue, L. J., Macneil, C., Scott, E. M. et al. (2015). An evidence map of psychosocial interventions for the earliest stages of bipolar disorder. Lancet Psychiatry, 2, 548563. doi: https://doi.org/10.1016/S2215-0366(15)00156-XGoogle Scholar
Whiteford, H. A., Harris, M. G., McKeon, G., Baxter, A., Pennell, C., Barendregt, J. J. and Wang, J. (2013). Estimating remission from untreated major depression: a systematic review and meta-analysis. Psychological Medicine, 43, 15691585. doi: 10.1017/s0033291712001717Google Scholar
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