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Dietary conjugated linoleic acids promote fatty streak formation in the C57BL/6 mouse atherosclerosis model

Published online by Cambridge University Press:  09 March 2007

John S. Munday ,
Keith G. Thompson  and
Kerry A. C. James
John S. Munday*
Affiliation:
Institute of Veterinary, Animal and Biomedical Sciences Massey University, Palmerston North, New Zealand
Keith G. Thompson
Affiliation:
Institute of Veterinary, Animal and Biomedical Sciences Massey University, Palmerston North, New Zealand
Kerry A. C. James
Affiliation:
New Zealand Institute for Crop and Food Research Limited, Palmerston North, New Zealand
*
*Corresponding author: Dr John S. Munday, fax +646 350 2270, email munday@ahdlms.cvm.msu.edu
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Abstract

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Conjugated linoleic acids (CLA) are positional isomers of linoleic acid which have been suggested by some to possess antiatherosclerotic properties. To test this hypothesis, three groups of twenty C57BL/6 mice were fed on atherogenic diets containing: 5 g CLA/kg, 2·5 g CLA + 2·5 g linoleic acid/kg or 5 g linoleic acid/kg. All diets were fed for 15 weeks and contained (g/kg): triacylglycerol 145, free fatty acids 5, cholesterol 10 and cholic acid 5. At the completion of the experimental period, when data from both groups fed on CLA were combined, dietary CLA did not produce significant differences in body weight, serum total cholesterol concentration or serum HDL-cholesterol concentration. However, mice receiving CLA developed a significantly higher serum HDL-cholesterol: total cholesterol ratio and a significantly lower serum triacylglycerol concentration than controls. Despite causing a serum lipoprotein profile considered to be less atherogenic, the addition of CLA to the atherogenic diet increased the development of aortic fatty streaks. Considering the increased atherogenesis associated with dietary CLA in the present study, and the failure to demonstrate a significant beneficial effect of CLA in other animal studies, there is currently no conclusive evidence to support the hypothesis that CLA protect against atherogenesis.

Keywords

AtherosclerosisConjugated linoleic acidsDietary fat
Type
Research Article
Information
British Journal of Nutrition , Volume 81 , Issue 3 , March 1999 , pp. 251 - 255
Copyright
Copyright © The Nutrition Society 1999

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