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The effect of dietary fibre on bile acid metabolism in rats

Published online by Cambridge University Press:  25 February 2008

W. G. Brydon ,
K. Tadessea ,
M. A. Eastwood  and
Margaret E. Lawson
W. G. Brydon
Affiliation:
Wolfson Laboratories, Gastro-Intestinal Unit, Department of Medicine, Western General Hospital, Edinburgh EH4 2XU
K. Tadessea
Affiliation:
Wolfson Laboratories, Gastro-Intestinal Unit, Department of Medicine, Western General Hospital, Edinburgh EH4 2XU
M. A. Eastwood
Affiliation:
Wolfson Laboratories, Gastro-Intestinal Unit, Department of Medicine, Western General Hospital, Edinburgh EH4 2XU
Margaret E. Lawson
Affiliation:
Department of Biochemistry, University of Edinburgh, Edinburgh EHS 9AG
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Abstract

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1. Forty-eight male rats were fed sequentially for 14 d periods on diets containing different fibre contents.

2. One of the high-fibre diets was a commercial pelleted diet. The other was a low-fibre diet supplemented with 200 g wheat bran/kg.

3. At the end of each feeding period eight rats were killed. Liver microsomal cholesterol 7α-hydroxylase (EC 1.14.1.-) activity and bile acid content of small intestine and colon were determined.

4. The different diets did not significantly alter the total intestinal bile acids, but affected the distribution and qualitative pattern in the colon and small intestine.

5. On the high-fibre diets deoxycholate, and hyodeoxycholate tended to be increased.

6. On the low-fibre diets the α-, β- and ω-muricholic acids tended to be increased.

7. Liver microsomal cholesterol 7α-hydroxylase activity was lower in rats fed on the low-fibre and bran- supplemented low-fibre diets compared with that in rats fed on the commercial pelleted diet.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 43 , Issue 1 , January 1980 , pp. 101 - 106
Copyright
Copyright © The Nutrition Society 1980

References

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