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The effect of different dietary fats on gastrin levels in the pyloric antrum and plasma of weaner and adult Wistar rats

Published online by Cambridge University Press:  09 March 2007

N. U. Ekeke ,
C. Shaw ,
C. F. Johnston ,
K. D. Buchanan  and
A. H. G. Love
N. U. Ekeke
Affiliation:
Department of Medicine, The Queen's University of Belfast, Grosvenor Road, Belfast BTI2 6BJ
C. Shaw
Affiliation:
Department of Medicine, The Queen's University of Belfast, Grosvenor Road, Belfast BTI2 6BJ
C. F. Johnston
Affiliation:
Department of Medicine, The Queen's University of Belfast, Grosvenor Road, Belfast BTI2 6BJ
K. D. Buchanan
Affiliation:
Department of Medicine, The Queen's University of Belfast, Grosvenor Road, Belfast BTI2 6BJ
A. H. G. Love
Affiliation:
Department of Medicine, The Queen's University of Belfast, Grosvenor Road, Belfast BTI2 6BJ
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Abstract

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The effect of dietary fats on gastrin in the pyloric antrum and plasma of Wistar rats was examined. Two different age-groups of rats were fed on three different diets in which fat was in the form of menhadenoil (MO), hydrogenated coconut oil (CO) and safflower oil (SO) respectively. Control groups were fed on normal laboratory diet. Each diet was isoenergetic and no group showed significant differences in either food intake or weight gain during the experiment. Weaner rats fed on the MO diet exhibited significant reductions in both antral (P = 0.047) and plasma (P = 0.002) gastrin concentrations when compared with age-matched controls. Likewise, adult rats fed on the MO diet exhibited significant reductions in both antral (P = 0.008) and plasma (P = 0.002) gastrin concentrations. In addition, adult rats fed on the CO diet exhibited significant reductions in both antral (P = 0.047) and plasma gastrin(P = 0.002) concentrations. Rats from both age-groups fed on the SO diet exhibited no significant differences in gastrin concentrations when compared with their respective control groups. These findings indicate that the composition of dietary fat can have profound effects on both tissue and plasma concentrations of gastrin in rats.

Keywords

GastrinFat intakeRat
Type
Metabolic Effects of Fats
Information
British Journal of Nutrition , Volume 69 , Issue 1 , January 1993 , pp. 151 - 157
Copyright
Copyright © The Nutrition Society 1993

References

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