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The effect of trenbolone acetate with time on the various responses of protein synthesis of the rat

Published online by Cambridge University Press:  09 March 2007

B. G. Vernon  and
P. J. Buttery
B. G. Vernon
Affiliation:
Department of Applied Biochemistry and Nutrition, University of Nottingham School of Agriculture, Sutton Bonington, Loughborough, Leics.
P. J. Buttery
Affiliation:
Department of Applied Biochemistry and Nutrition, University of Nottingham School of Agriculture, Sutton Bonington, Loughborough, Leics.
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Abstract

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1. The anabolic agent trenbolone acetate (3-oxo-17 β-hydroxy-4,9, 11-oestratriene acetate; TBA) given subcutaneously to female rats increased their growth rate compared with that of the placebo-treated controls.

2. The increased growth rate of the TBA-treated rats was not a consequence of an increased water retention. The TBA-treated rats had a significantly higher (P < 0.01) total carcass nitrogen content but the total carcass fat content decreased by a non-significant (P > 0.05) 8.3%.

3. There was evidence of a time-lag in the response of the fractional synthetic rate of certain individual tissues to TBA. The fractional synthetic rates of the uterus and skeletal muscle mixed tissue proteins were significantly reduced in the TBA-treated rats.

4. The measured reduction in fractional synthetic rates was concluded to reflect true changes in the synthetic rate rather than a result of an alteration in the specific activity of the tyrosine pool used for protein synthesis.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 40 , Issue 3 , November 1978 , pp. 563 - 572
Copyright
Copyright © The Nutrition Society 1978

References

Association of, Official Agricultural Chemists (1970). Official Methods of Analysis, 11th ed.Washington DC: Association of Official Agricultural Chemists.Google Scholar
Atkin, G. E. & Ferdinand, W. (1970). Analyt. Biochem. 38, 313.CrossRefGoogle Scholar
Aub, M. R. & Waterlow, J. C. (1970). J. theor. Biol. 26, 243.CrossRefGoogle Scholar
Baxter, J. D. & Forsham, P. H. (1972). Am. J. Med. 53, 573.CrossRefGoogle Scholar
Beato, M., Kalini, D. & Feigelson, P. (1972). Biochem. biophys. Res. Commun. 47, 1464.CrossRefGoogle Scholar
Burton, K. (1956). Biochem. J. 62, 315.CrossRefGoogle Scholar
Chan, K. H., Heitzman, R. J. & Kitchenham, B. A. (1975). Br. vet. J. 131, 170.CrossRefGoogle Scholar
Clemens, M. J. & Pain, V. M. (1976). In Protein Metabolism and Nutrition, p. 19 [Cole, D. J. A., Boorman, K. N. P., Buttery, J., Lewis, D., Neale, R. J. and Swan, H., editors]. London: Butterworths.Google Scholar
Dube, J. Y., Lesage, R. & Tremblay, R. R. (1976). Can. J. Biochem. Physiol. 54, 50.Google Scholar
Fern, E. B. & Garlick, P. J. (1974). Biochem. J. 142 413.CrossRefGoogle Scholar
Garlick, P. J., Millward, D. J. & James, W. P. T. (1973). Biochem. J. 136, 935.CrossRefGoogle Scholar
Garlick, P. J., Millward, D. J., James, W. P. T. & Waterlow, J. C. (1975). Biochim. biophys. Acta 414, 71.CrossRefGoogle Scholar
Goldberg, A. L. (1969 a). J. biol. Chem. 244, 3217.CrossRefGoogle Scholar
Goldberg, A. L. (1969 b). J. biol. Chem. 244, 3223.CrossRefGoogle Scholar
Goldberg, A. L. & Dice, J. F. (1974). A. Rev. Biochem. 43, 835.CrossRefGoogle Scholar
Goldberg, A. L., Howell, E. M., Li, J. B., Martel, S. B. & Prouty, W. F. (1974). Fedn Proc. Fedn Am. Socs exp. Biol. 33, 1112.Google Scholar
Gustafsson, J-A. & Pousette, A. (1975). Biochemistry, Easton 14, 3094.CrossRefGoogle Scholar
Hider, R. C., Fern, E. B. & London, D. R. (1971). Biochem. J. 121, 817.CrossRefGoogle Scholar
Jefferson, L. S. & Korner, A. (1969). Biochem. J. 111, 703.CrossRefGoogle Scholar
Jefferson, L. S., Schworer, C. M. & Tolman, E. L. (1975). J biol. Chem. 250, 197.CrossRefGoogle Scholar
Jensen, E. V. & DeSombre, E. R. (1972). A, Rev. Biochem. 41, 203.CrossRefGoogle Scholar
Kerr, S. E. & Seraidorian, K. (1945). J. biol. Chem. 159, 211.CrossRefGoogle Scholar
Kochakian, C. D. & Murlin, J. R. (1935). J. Nutr. 10, 437.CrossRefGoogle Scholar
Kruskemper, H. L. (1968). In Anabolic Steroids, [Doering, C. H.]. London: Academic Press.Google Scholar
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). J. biol. Chem. 193, 265.CrossRefGoogle Scholar
Manchester, K. L. (1976). In Protein Metabolism and Nutrition, p. 35 [Cole, D. J. A., Boorman, K. N., Buttery, P. J., Lewis, D., Neale, R. J. and Swan, H., editors]. London: Butterworths.Google Scholar
Mayer, M. & Rosen, F. (1975). Am. J. Physiol. 229, 1381.CrossRefGoogle Scholar
Millward, D. J. & Garlick, P. J. (1972). Proc. Nutr. Soc. 31, 257.CrossRefGoogle Scholar
Millward, D. J., Garlick, P. J., James, W. P. T., Nnanyelugo, D. O. & Ryatt, J. S. (1973). Nature, Lond. 241, 204.CrossRefGoogle Scholar
Millward, D. J., Garlick, P. J., Nnanyelugo, D. O. & Waterlow, J. C. (1976). Biochem. J. 156, 185.CrossRefGoogle Scholar
Millward, D. J., Garlick, P. J., Stewart, R. J. C., Nnanyelugo, D. O. & Waterlow, J. C. (1975). Biochem. J. 150, 235.CrossRefGoogle Scholar
Morgan, H. E., Earl-Broadus, A., Wolpert, E. B., Geiger, K. E. & Jefferson, L. S. (1971). J. biol. Chem. 246, 2152.CrossRefGoogle Scholar
Mueller, E. E. (1974). In Physiology 1, Vol.5, Endocrine Physiology, p. 141 [McCann, S. M., editor]. London: Butterworths.Google Scholar
Munro, H. N. & Fleck, A. (1969). In Mammalian Protein Metabolism Vol. 3, p. 424 [Munro, H. N., editor]. New York: Academic Press.Google Scholar
O'Malley, B. & Schrader, W. T. (1976). Scient. Am. 234, 32.CrossRefGoogle Scholar
Pottier, J., Busigny, M. & Grandadam, J. A. (1975). J. Anim. Sci. 41, 962.CrossRefGoogle Scholar
Preston, R. L. (1975). J. Anim. Sci. 41, 1414.CrossRefGoogle Scholar
Scharff, R. & Wool, I. G. (1965). Biochem. J. 97, 257.CrossRefGoogle Scholar
Schimke, R. T. & Doyle, D. (1970). A Rev. Biochem. 39, 929.CrossRefGoogle Scholar
Stein, W. H. & Moore, S. (1954). J. biol. Chem. 211, 915.CrossRefGoogle Scholar
Tremblay, R. R., Dube, J. Y., Horkim, M. A. & Lesage, R. (1977). Steroids 29, 185.CrossRefGoogle Scholar
Vernon, B. G. & Buttery, P. J. (1976). Br. J. Nutr. 36, 575.CrossRefGoogle Scholar
Vernon, B. G. & Buttery, P. J. (1978). Anim. Prod. (In the Press).Google Scholar
Vidrich, A., Airhart, J., Bruno, M. K. & Khairallah, E. A. (1977). Biochem. J. 162, 257.CrossRefGoogle Scholar
Waterlow, J. C. & Stephen, J. M. L. (1968). Clin. Sci. 33, 489.Google Scholar
Young, V. R. & Pluskal, M. G. (1977). Proc. 2nd int. Symp. Protein Metabolism and NutritionThe Netherlands, p. 17.Google Scholar