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Effects of an iron supplementation trial on the Fe status of Thai schoolchildren

Published online by Cambridge University Press:  09 March 2007

Phongjan Hathirat ,
Aree Valyasevi ,
Nittaya J. Kotchabhakdi ,
Nipa Rojroongwasinkul  and
Ernesto Pollitt
Phongjan Hathirat
Affiliation:
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Aree Valyasevi
Affiliation:
Institute of Nutrition, Mahidol University, Bangkok, Thailand
Nittaya J. Kotchabhakdi
Affiliation:
Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Nipa Rojroongwasinkul
Affiliation:
Institute of Nutrition, Mahidol University, Bangkok, Thailand
Ernesto Pollitt
Affiliation:
Department of Pediatrics, School of Medicine and Program of International Nutrition, University of California, Davis, California, USA
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Abstract

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A double-blind clinical trial was conducted among 9- to 11-year-old children in sixteen schools in the Chon Buri province of Thailand to assess the effects of an iron supplement combined with an anthelminthic agent (i.e. albendazole). In addition to the albendazole, Fe or placebo tablets were distributed to 2268 children enrolled in grades three to five without knowledge of the Fe status of the children. Criteria for case inclusion were: (a) absence of A E Bart's or haemoglobin (Hb) H disease, (b) absence of abnormal Hb EE, and (c) age, 108–144 months. The results showed a significant improvement in the Fe status of the children after 16 weeks of treatment. The increments were: Hb from 124 to 128 g/l, serum ferritin from 34.54 to 104.72 μg/l, transferrin saturation from 24.09 to 35.05%; free erythrocyte protoporphyrin decreased from 444.7 to 281.4 μg/l erythrocytes. These changes were significantly greater than in the control group that received only the anthelminthic agent. However, the administration of albendazole only also resulted in significant changes in the same Fe indicators.

Keywords

Iron supplementationThai schoolchildren
Type
Mineral Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 1 , July 1992 , pp. 245 - 252
Copyright
Copyright © The Nutrition Society 1992

References

REFERENCES

Areekul, S., Devakul, K., Smitananda, N., Boonyananta, C. & Klongkumnuangarn, K. (1972). Prevalence of anaemia in Thai school children. Journal of the Medical Association of Thailand 55, 457–463.Google ScholarPubMed
Bogan, J. A. & Marriner, S. E. (1984). Pharmacodynamic and toxicological aspects of albendazole in man and animals. In Albendazole in Helminthiasis, Royal Society of Medicine International Congress and Symposium Series no. 61. pp. 13–27 [Firth, M., editor]. London: Royal Society of Medicine.Google Scholar
Charoenlarp, P., Dhanamitta, S., Kaewvichit, R., Silprasert, A., Suwanaradd, C., Na-Nakorn, S., Prawatmuang, P., Vatanavicharn, S., Nutcharas, U., Pootrakul, P., Tanphaichitr, V., Thanangkul, O., Vaniyapong, T., Toe, Thane, Valyasevi, A., Baker, S., Cook, J., DeMaeyer, E. M., Garby, L. & Hallberg, L. (1988). A WHO collaborative study on iron supplementation in Burma and in Thailand. American Journal of Clinical Nutrition 47, 280–297.CrossRefGoogle Scholar
Gammeck, D. B., Huehns, E. R., Shooter, E. M. & Gerald, P. S. (1960). Identification of the abnormal polypeptide chain of hemoglobin G16. Journal of Molecular Biology 2, 372–378.CrossRefGoogle Scholar
Garby, L. & Areekul, S. (1974). Iron supplementation in Thai fish-sauce. The Annual of Tropical Medicine & Parasitology 68, 467–476.CrossRefGoogle ScholarPubMed
Na-Nakorn, S. (1979). Deficiency anemia in Thailand. In Proceedings of the Fourth Meeting of the Asian-Pacific Division International Society of Hematology, Seoul, pp. 147–155. Seol: International Society of Haematology.Google Scholar
Na-Nakorn, S., Minnich, V. & Chernoff, A. I. (1956). Studies on hemoglobin E. II. The incidence of hemoglobin E in Thailand. Journal of Laboratory and Clinical Medicine 47, 490–498.Google ScholarPubMed
National Statistical Office (1982). Statistical Reports of Changwat Chon Buri. Bangkok: Office of the Prime Minister.Google Scholar
Pollitt, E., Hathirat, P., Kotchabhakdi, N. J., Missell, L. & Valyasevi, A. (1989). Iron deficiency and educational achievement in Thailand. International Conference on Iron Deficiency and Behavioral Development. American Journal of Clinical Nutrition 50, Suppl., 687–697.CrossRefGoogle Scholar
Rigas, D. A., Koler, R. D. & Osgood, E. E. (1956). Hemoglobin H. Journal of Laboratory and Clinical Medicine 47, 51–64.Google ScholarPubMed
Rossignol, J. F. (1984). Double-blind placebo-controlled clinical trial of albendazole: world summary. In Albendazole in Helminthiasis, Royal Society of Medicine International Congress and Symposium Series no. 61. pp. 23–27 [Firth, M., editor]. London: Royal Society of Medicine.Google Scholar
Sanguansermsri, T., Makornkaewkayoo, L. & Yaemniyom, S. (1987). Diagnosis of alpha-thalassemia trait by mean of solid-phase 2 sites immunoradiometric assay (SPTIRMA) of Hb-Bart's. Presented at the Annual Meeting of the Society of Hematology of Thailand, Bangkok.Google Scholar
Toewsiri, P. (1977). Simple determination of Hb A2 for detection of heterozygous beta-thalassemia. Bulletin of the Chiangmai Association of Medicine 10, 17–24.Google Scholar
Wasi, P., Na-Nakorn, S. & Pootrakul, S. (1969). Alpha- and beta-thalassemia in Thailand. Annals of the New York Academy of Sciences 165, 60–82.CrossRefGoogle ScholarPubMed
Weatherall, D. J. & Clegg, J. B. (1981). The Thalassemia Syndromes, 3rd ed. Oxford: Blackwell.Google Scholar