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Effects of whey protein, casein, soya-bean and sunflower proteins on the serum, tissue and faecal steroids in rats*

Published online by Cambridge University Press:  09 March 2007

C. Sautier ,
K. Dieng ,
C. Flament ,
C. Doucet ,
J. P. Suquet  and
D. Lemonnier
C. Sautier
Affiliation:
Unité de Recherches sur la Nutrition et l' Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75877 Paris Cédex 18, France
K. Dieng
Affiliation:
Unité de Recherches sur la Nutrition et l' Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75877 Paris Cédex 18, France
C. Flament
Affiliation:
Unité de Recherches sur la Nutrition et l' Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75877 Paris Cédex 18, France
C. Doucet
Affiliation:
Unité de Recherches sur la Nutrition et l' Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75877 Paris Cédex 18, France
J. P. Suquet
Affiliation:
Unité de Recherches sur la Nutrition et l' Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75877 Paris Cédex 18, France
D. Lemonnier
Affiliation:
Unité de Recherches sur la Nutrition et l' Alimentation, U.1. INSERM, Hôpital Bichat, 170 Bd. Ney, 75877 Paris Cédex 18, France
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Abstract

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1. Four groups of rats were fed for 49 d on one of four semi-purified diets, without added cholesterol and containing 230 g/kg of the following isolated proteins: casein, whey, soya-bean or sunflower.

2. Whey, soya-bean and sunflower proteins, when compared with casein, decreased the level of serum high-density-lipoprotein (HDL)-cholesterol. These low cholesterol levels were accompanied by an increase in the daily faecal excretion of neutral sterols and bile acids in the case of soya-bean protein, and by a decrease in the liver cholesterol content, when rats were fed on whey protein.

3. Considering the amino acid composition of the four purified proteins, we observed that serum total and HDL-cholesterol levels had a significant positive correlation with tyrosine and glutamic acid, and a negative correlation with cystine and alanine.

4. The present study showed that the hypocholesterolaemic effect of dietary proteins was not related to their animal or vegetable origin.

Type
Paper of diract relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 49 , Issue 3 , May 1983 , pp. 313 - 319
Copyright
Copyright © The Nutrition Society 1983

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