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Energy balance and body-weight stability: impact of gene–environment interactions

Published online by Cambridge University Press:  09 March 2007

Angelo Tremblay ,
Louis Pérusse  and
Claude Bouchard
Angelo Tremblay*
Affiliation:
Division of Kinesiology and Functional Foods, Laval University, Ste-Foy, Québec, Canada, G1K 7P4 Institute of Nutraceuticals and Functional Foods, Laval University, Ste-Foy, Québec, CanadaG1K 7P4
Louis Pérusse
Affiliation:
Division of Kinesiology and Functional Foods, Laval University, Ste-Foy, Québec, Canada, G1K 7P4
Claude Bouchard
Affiliation:
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge LA 70808, USA
*
*Corresponding author: Dr Angelo Tremblay, fax +1 418 656 2441, email angelo.tremblay@kin.mso.ulaval.ca
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Abstract

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Studies of monozygotic twins in the context of overfeeding and energy deficit experiments have shown that gene–environment interactions affect energy balance. From a clinical standpoint, this implies that some individuals are more susceptible to body-weight gain or loss than others because of genetic differences. This opens new perspectives in predictive medicine. In the future, health professionals should be able to count on early diagnosis of individuals at risk for developing long-term metabolic problems and obesity or for not responding adequately to clinical interventions. However, before predictive medicine is in a position to contribute significantly to prevention or treatment of patients, an enormous amount of work has to be done to identify all genetic and environmental factors of relevance, and their network of interactions.

Keywords

ObesityGenotypeEnergy
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue S1 , August 2004 , pp. S63 - S66
Copyright
Copyright © The Nutrition Society 2004

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