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Faecal dry weight and potassium are related to faecal sodium and plasma aldosterone in rats chronically fed on varying amounts of sodium or potassium chlorides

Published online by Cambridge University Press:  09 March 2007

Richard D. McCabe ,
Manis J. Smith Jr  and
Terry M. Dwyer
Richard D. McCabe
Affiliation:
The Department of Physiology and Biophysics, The University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216-4505, USA
Manis J. Smith Jr
Affiliation:
The Department of Physiology and Biophysics, The University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216-4505, USA
Terry M. Dwyer
Affiliation:
The Department of Physiology and Biophysics, The University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi 39216-4505, USA
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Abstract

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Recent studies have shown that faecal residue (dry weight) and Na and K increase with increasing levels of dietary fibre, an effect which may be related to unstirred layers that slow absorption and the flow rate of chyme through the gastrointestinal tract. Salts of Na are the primary osmotic components of chyme and influence both retention of fluid in the bowel and transit of fluid from the small to the large intestine. The present study examines the chronic effects of dietary Na and K intake on faecal Na, K and residue excretion. Male Sprague-Dawley rate were given 12–13 g feed/d (control (g/kg): Na 4, K 8.5) for 1 week, followed by a 4-week period where Na or K intake was altered (0.01–3 times control levels). These diets altered chronic (> 1 week) faecal residue excretion and affected Na and K excretion by 8-, 310-and 2100-fold respectively. Low dietary Na reduced faecal Na and residue; K excretion was doubled during week 1, but fell over weeks 2–4 despite a 4–5-fold increase in plasma aldosterone. Chronic high dietary Na increased faecal Na, residue and K despite a 60% decrease in plasma aldosterone. Chronic low dietary K decreased faecal Na, K and residue and plasma aldosterone. Chronic high dietary K did not alter faecal Na and K despite increased faecal residue and a 4–5-fold increase in plasma aldosterone. Faecal water was unchanged by diet, paralleling changes in faecal residue. Analyses of the results provide systematic models of chronic regulation of faecal Na, K and residue excretions. When plasma aldosterone is low (< 160 ng/I), weekly faecal residue excretion is equal to 3.6 g (fibre intake was 2.6–2.7 g/week) + 2.6 g/mmol Na, and K excretion is equal to 0.55 mmol/mmol Na. When plasma aldosterone is high (> 1500 ng/I) weekly faecal residue excretion is equal to 2.3 g + 2.6 g/mmol Na, and K excretion is equal to 0.7 mmol/week + 0.55 mmol/mmol Na.

Keywords

SodiumPotassiumAldosteroneFaecesRat
Type
Effects of sodium and potassium chlorides on faecal composition
Information
British Journal of Nutrition , Volume 72 , Issue 2 , August 1994 , pp. 325 - 337
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Bandaru, S. R. (1990). Effect of types of dietary fiber on fecal mutagens and bacterial enzymes in relation to colon cancer. In New Developments in Dietary Fiber, pp. 159–166 [Furda, L. and Brine, C. J., editors]. New York: Plenum Press.Google Scholar
Blanchley, J. D., Crider, B. P. & Johnson, J. H. (1986). Extrarenal potassium adaptation: role of skeletal muscle. American Journal of Physiology 251, F313–F318.Google Scholar
Chabert, P. R., Guelpa-Decorzent, C., Riondel, A. M. & Vallotton, M. B. (1984). Effect of spironolactone on electrolytes, renin, ACTH and corticosteroids in the rat. Journal of Steroid Biochemistry 20, 1253–1259.CrossRefGoogle ScholarPubMed
Charney, A. N., Kinsley, D., Meyers, L., Giannella, R. A. & Gots, R. E. (1975). Na, K-activated adenosine triphosphate and intestinal electrolyte transport. Journal of Clinical Investigation 56, 653–660.CrossRefGoogle Scholar
Charron, R. C., Leme, C. E., Wilson, D. R., Ing, T. S. & Wrong, O. M. (1974). The effect of adrenal steroids on stool composition as revealed by in vitro dialysis of feces. Clinical Science 227, 345–350.Google Scholar
Curran, P. F. & Solomon, A. K. (1957). Ions and water fluxes in the ileum of rats. Journal of General Physiology 41, 143–168.CrossRefGoogle ScholarPubMed
Debongie, J. C. & Phillips, S. F. (1978). Capacity of the human colon to absorb fluid. Gastroenterology 74, 698–703.CrossRefGoogle Scholar
Dietschey, J. M., Sallee, V. L. & Wilson, F. A. (1971). Unstirred water layers and absorption across intestinal mucosa. Gastroenterology 61, 932–934.CrossRefGoogle Scholar
Dunnett, C. W. (1955). A multiple procedure for comparing several treatments with a control. Journal of the American Statistical Association 50, 1096–1121.CrossRefGoogle Scholar
Eastwood, M. A.Mitchell, W. D. & Pritchard, J. L. (1980). The effect of bran on excretion of faecal cations. Proceedings of the Nutrition Society 35, 78A–79A.Google Scholar
Edmonds, C.J. (1967). The gradient of electrical potential difference and sodium and potassium on the gut contents along the cecum and colon of normal and sodium-depleted rats. Journal of Physiology 193, 571–588.CrossRefGoogle ScholarPubMed
Edwards, C. (1990). Mechanism of action of dietary fiber on small intestinal absorption and motility. In New Developments in Dietary Fiber, pp. 95–104 [Furda, I. and Brine, C. J., editors]. New York: Plenum Press.CrossRefGoogle Scholar
Field, H., Dailey, R. E., Boyd, R. S. & Swell, L. (1954). Effect of restriction of dietary sodium on electrolyte composition of the contents of the terminal ileum. American Journal of Physiology 179, 477–480.CrossRefGoogle ScholarPubMed
Fluorie, B., Vidon, N., Florent, C. H. & Bernier, J. H. (1984). Effect of pectin on jejunal glucose absorption in normal man. Gut 25, 936–941.CrossRefGoogle Scholar
Fordtran, J. S. & Locklear, T. W. (1966). Ionic constituents and osmolarity of gastric and small intestinal fluids after eating. American Journal of Digestive Diseases 11, 503–521.CrossRefGoogle Scholar
Fordtran, J. S., Rector, F. C., Enton, M. F., Suter, N. & Kinney, J. (1965). Permeability characteristics of the human small intestine. Journal of Clinical Investigation 44, 1935–1944.CrossRefGoogle ScholarPubMed
Foster, E. S., Sandle, G. I., Hayslett, J. P. & Binder, H. J. (1986). Dietary potassium modulates active potassium absorption and secretion in rat distal colon. American Journal of Physiology 251, G619–G626.Google ScholarPubMed
Frizzell, R. A., Koch, M. J. & Schultz, S. G. (1976). Ion transport by rabbit colon: I. Active and passive components. Journal of Membrane Biology 27, 297–316.CrossRefGoogle Scholar
Frizzell, R. A. & Schultz, S. G. (1978). Effects of aldosterone on ion transport by rabbit colon in-vitro. Journal of Membrane Biology 39, 1–26.CrossRefGoogle ScholarPubMed
Fuse, K., Bamba, T. & Hoso, S. (1989). Effects of pectin on fatty acid and glucose absorption and unstirred water layer in rat and human intestine. Digestive Diseases and Sciences 34, 1109–1116.CrossRefGoogle ScholarPubMed
Gotch, F., Nadell, J. & Edelman, I. S. (1957). Gastrointestinal water and electrolytes. IV. The equilibration of deuterium oxide (D, O) in gastrointestinal contents and the proportion of total body water (TBW) in the gastrointestinal tract. Journal of Clinical Investigation 36, 289–296.CrossRefGoogle Scholar
Holbrook, J. T., Patterson, K. Y., Bodner, J. E., Douglas, L. W., Vellon, C., Kelsay, J. L., Mertz, W. & Smith, J. C. (1984). Sodium and potassium intake and balance in adults consuming self-selected diets. American Journal of Clinical Nutrition 40, 786–793.CrossRefGoogle ScholarPubMed
Jeraci, J. L. & Van Soest, P. J. (1990). Improved methods for analysis of biological characterization of fiber. In New Developments in Dietary Fiber, pp. 145–163 [Furda, I. and Brine, C. J., editors]. New York: Plenum Press.Google Scholar
Johnson, I. T. & Gee, J. M. (1981). Effect of gel-forming food gums on the intestinal unstirred layer and sugar transport in-vitro. Gut 22, 398–403.CrossRefGoogle Scholar
Judd, P. A. & Trusell, S. A. (1981). The effect of rolled oats on blood lipids and fecal steroid excretion in man. American Journal of Clinical Nutrition 34, 2061–2067.CrossRefGoogle ScholarPubMed
McCabe, R. D., Cooke, H. J. & Sullivan, L. P. (1982). Potassium transport by rabbit descending colon. American Journal of Physiology 242, C81–C86.CrossRefGoogle ScholarPubMed
McCabe, R. D., Smith, P. L. & Sullivan, L. P. (1984). Ion transport by rabbit descending colon: mechanisms of transepithelial potassium transport. American Journal of Physiology 246, G594–G602.Google ScholarPubMed
Mohring, J. & Mohring, B. (1972). Evaluation of sodium and potassium balance in rats. Journal of Applied Physiology 33, 688–692.CrossRefGoogle ScholarPubMed
Murray, D., Fleiszer, D., McArdle, A. H. & Brown, R. A. (1980). Effect of dietary fiber on intestinal mucosal sodium-potassium-activated ATPase. Journal of Surgical Research 29, 135–140.CrossRefGoogle ScholarPubMed
Phillips, S. F. (1969). Absorption and secretion by the colon. Gastroenterology 56, 566–571.CrossRefGoogle ScholarPubMed
Phillips, S. F. & Giller, J. (1973). The contributions of the colon to electrolyte and water conservation in man. Journal of Laboratory and Clinical Medicine 81, 733–146.Google ScholarPubMed
Rabelink, T. J., Koomans, H. A., Hene, R. J. & Dorhout-Mees, E. J. (1990). Early and late adaptations to potassium loading in humans. Kidney International 38, 942–947.CrossRefGoogle ScholarPubMed
Sandle, G. I., Foster, E., Lewis, S., Binder, H. J. & Hayslett, J. P. (1985). The electrical basis of enhanced potassium secretion in rat distal colon during dietary potassium loading. Pflügers Archives 403, 433–439.CrossRefGoogle ScholarPubMed
Sealey, J. E., Clark, I., Bull, M. B. & Laragh, J. H. (1970). Potassium balance and the control of renin secretion. Journal of Clinical Investigation 49, 2119–2127.CrossRefGoogle ScholarPubMed
Spiller, G. A., Story, J. A., Wong, L. G., Nunes, J. D., Alton, M., Petro, M. S., Furomoto, J. D., Whittam, J. H. & Scala, J. (1986). Effect of increasing levels of hard wheat fiber on fecal weight, minerals, steroids and gastrointestinal transit time in healthy young women. Journal of Nutrition 116, 778–785.CrossRefGoogle ScholarPubMed
Thompson, S. M., Suzuki, Y. & Schultz, S. G. (1982). The electrophysiology of rabbit descending colon. 11. Current-voltage relations of the apical membrane, the basolateral membrane and the parallel pathways. Journal of Membrane Biology 66, 41–54.CrossRefGoogle Scholar
Wills, N. K. & Biagi, B. (1982). Active potassium transport by rabbit descending colon. Journal of Membrane Biology 64, 195–203.CrossRefGoogle ScholarPubMed
Zar, J. H. (1974). Simple linear regression. In Biostatistical Analysis, pp. 198–227. Englewood Cliffs: Prentice-Hall.Google Scholar