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Non-digestible oligosaccharides and calcium absorption in girls with adequate calcium intakes †

Published online by Cambridge University Press:  09 March 2007

I. J. Griffin ,
P. M. Davila  and
S. A. Abrams
I. J. Griffin*
Affiliation:
USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
P. M. Davila
Affiliation:
USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA
S. A. Abrams
Affiliation:
USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates Street, Houston, TX 77030, USA Section of Neonatology, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
*
*Corresponding author: Dr I. Griffin, fax +1 713 798-7119, email igriffin@neo.bcm.tmc.edu
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Abstract

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Non-digestible oligosaccharides such as inulin and oligofructose have been shown to consistently increase calcium absorption in experimental animals, but data in humans are less clear-cut. The objective of this study was to assess the effect of 8 g/d of oligofructose or a mixture of inulin and oligofructose on calcium absorption in girls at or near menarche. A total of fifty-nine subjects were studied using a balanced, randomized, cross-over design. They received, in random order, 8 g/d placebo (sucrose), oligofructose or the mixture inulin+oligofructose for 3 weeks, separated by a 2-week washout period. Throughout the study, subjects consumed a total of approximately 1500 mg/d dietary calcium, by adding two glasses of calcium-fortified orange juice to their diet. Four grams of placebo, oligofructose or the mixture inulin+oligofructose was added to each glass of orange juice immediately before it was consumed. At the end of each 3-week adaptation period, calcium absorption was measured, using a dual stable isotope technique, from the cumulative fractional excretion of an oral and an intravenous tracer over 48 hours. Calcium absorption was significantly higher in the group receiving the inulin+oligofructose mixture than in the placebo group (38·2±9·8 % v. 32·3±9·8 %; P=0·01), but no significant difference was seen between the oligofructose group and the placebo group (31·8±9·3 % v. 31·8±10·0 %, P=NS). We conclude that modest intakes of an inulin+oligofructose mixture increases calcium absorption in girls at or near menarche.

Keywords

Calcium absorptionNon-digestible oligosaccharidesOligofructoseInulinPrebioticsStable isotope
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S2 , May 2002 , pp. S187 - S191
Copyright
Copyright © The Nutrition Society 2002

Footnotes

Supported in part with federal funds from the USDA/ARS under Cooperative Agreement No. 58-6250-6-001. This work is a publication of the U.S. Department of Agriculture (USDA)/Agricultural Research Service (ARS) Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, Texas. Contents of this publication do not necessarily reflect the views or policies of the USDA, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This study was funded, in part, by ORAFTI, Tienen, Belgium.

References

Abrams, SA, Sidbury, JB, Muenzer, J, Esteban, NV, Vieira, NE & Yergey, AL (1991) Stable isotopic measurement of endogenous fecal calcium excretion in children. Journal of Pediatric Gastroenterology Nutrition 12, 469–473.Google ScholarPubMed
Abrams, SA & Stuff, JE (1994) Calcium metabolism in girls: current dietary intakes lead to low rates of calcium absorption and retention during puberty. American Journal of Clinical Nutrition 60, 739–743.CrossRefGoogle ScholarPubMed
Barger-Lux, MJ, Heaney, RP & Recker, RR (1989) Time course of calcium absorption in humans: evidence for a colonic component. Calcified Tissue International 44, 308–311.CrossRefGoogle ScholarPubMed
Briet, F, Achour, L, Flourie, B, Beaugerie, L, Pellier, P, Franchisseur, C, Bornet, F & Rambaud, JC (1995) Symptomatic response to varying levels of fructo-oligosaccharides consumed occasionally or regularly. European Journal of Clinical Nutrition 49, 501–507.Google ScholarPubMed
Brommage, R, Binacua, C, Antille, S & Carrie, AL (1993) Intestinal calcium absorption in rats is stimulated by dietary lactulose and other resistant sugars. Journal of Nutrition 123, 2186–2194.Google ScholarPubMed
Chan, GM (1991) Dietary calcium and bone mineral status of children and adolescents. American Journal of Diseases of Children 145, 631–634.Google ScholarPubMed
Chonan, O, Matsumoto, K & Watanuki, M (1995) Effect of galactooligosaccharides on calcium absorption and preventing bone loss in ovariectomized rats. Bioscience Biotechnology and Biochemistry 59, 236–239.CrossRefGoogle ScholarPubMed
Chonan, O & Watanuki, M (1995) Effect of galactooligosaccharides on calcium absorption in rats. Journal of Nutritional Science and Vitaminology (Tokyo) 41, 95–104.CrossRefGoogle ScholarPubMed
Coudray, C, Bellanger, J, Castiglia-Delavaud, C, Rémésy, C, Vermorel, M & Rayssignuier, Y (1997) Effect of soluble or partly soluble dietary fibres supplementation on absorption and balance of calcium, magnesium, iron and zinc in healthy young men. European Journal of Clinical Nutrition 51, 375–380.CrossRefGoogle ScholarPubMed
Coudray, C & Fairweather-Tait, SJ (1998) Do oligosaccharides affect the intestinal absorption of calcium in humans? American Journal of Clinical Nutrition 68, 921–923.Google ScholarPubMed
Delzenne, N, Aertssens, J, Verplaetse, H, Roccaro, M & Roberfroid, M (1995) Effect of fermentable fructo-oligosaccharides on mineral, nitrogen and energy digestive balance in the rat. Life Sciences 57, 1579–1587.CrossRefGoogle ScholarPubMed
Eastell, R, Vieira, NE, Yergey, AL & Riggs, BL (1989) One-day test using stable isotopes to measure true fractional calcium absorption. Journal of Bone and Mineral Research 4, 463–468.CrossRefGoogle ScholarPubMed
Eck, LH & Hackett-Renner, C (1992) Calcium intake in youth: sex, age, and racial differences in NHANES II. Preventative Medicine 21, 473–482.CrossRefGoogle ScholarPubMed
Greger, JL (1999) Non-digestible carbohydrates and mineral bioavailability. Journal of Nutrition 129, 1434S–1435S.CrossRefGoogle Scholar
Hillman, LS, Tack, E, Covell, DG, Vieira, NE & Yergey, AL (1988) Measurement of true calcium absorption in premature infants using intravenous 46Ca and oral 44Ca. Pediatric Research 23, 589–594.CrossRefGoogle ScholarPubMed
Institute of Medicine Food and Nutrition Board's Standing Committee on the Scientific Evaluation of Dietary Intervals (1997) Calcium. In Dietary Reference Intervals for Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride, pp. 71–146. Washington, DC: National Academy Press.Google Scholar
Matkovic, V (1992) Calcium and peak bone mass. Journal of Internal Medicine 231, 151–160.CrossRefGoogle ScholarPubMed
Matkovic, V & Heaney, RP (1992) Calcium balance during human growth: evidence for threshold behavior. American Journal of Clinical Nutrition 55, 992–996.CrossRefGoogle ScholarPubMed
Moshfegh, AJ, Friday, JE, Goldman, JP & Ahuja, JK (1999) Presence of inulin and oligofructose in the diets of Americans. Journal of Nutrition 129, 1407S–1411S.CrossRefGoogle ScholarPubMed
Nieves, JW, Golden, AL, Siris, E, Kelsey, JL & Lindsay, R (1995) Teenage and current calcium intake are related to bone mineral density of the hip and forearm in women aged 30–39. years. American Journal of Epidemiology 141, 342–351.CrossRefGoogle ScholarPubMed
Rémésy, C, Levrat, MA, Gamet, L & Demigne, C (1993) Cecal fermentations in rats fed oligosaccharides (inulin) are modulated by dietary calcium level. American Journal of Physiology 264, G855–G862.Google ScholarPubMed
Roberfroid, MB (1999) Concepts in functional foods: the case of inulin and oligofructose. Journal of Nutrition 129, 1398S–1401S.CrossRefGoogle ScholarPubMed
Schulz, AG, Van Amelsvoort, JM & Beynen, AC (1993) Dietary native resistant starch but not retrograded resistant starch raises magnesium and calcium absorption in rats. Journal of Nutrition 123, 1724–1731.CrossRefGoogle Scholar
van den Heuvel, EG, Schaafsma, G, Muys, T & van Dokkum, W (1998) Non-digestible oligosaccharides do not interfere with calcium and nonheme-iron absorption in young, healthy men. American Journal of Clinical Nutrition 67, 445–451.CrossRefGoogle Scholar
van den Heuvel, EG, Muys, T, van Dokkum, W & Schaafsma, G (1999) Oligofructose stimulates calcium absorption in adolescents. American Journal of Clinical Nutrition 69, 544–548.CrossRefGoogle ScholarPubMed
Van Loo, J, Coussement, P, De Leenheer, L, Huybregs, H & Smits, G (1995) On the presence of inulin and oligofructose as natural ingredients in the Western diet. Critical Reviews of Food Science and Nutrition 35, 525–552.CrossRefGoogle ScholarPubMed
Van Loo, J, Cummings, J, Delzenne, N, Englyst, H, Franck, A, Hopkins, M, Kok, N, Macfarlane, G, Newton, D, Quigley, M, Roberfroid, M, van Vliet, T & van den Heuvel, E (1999) Functional food properties of non-digestible oligosaccharides: a consensus report from the ENDO project (DGXII AIRII-CT94-1095). British Journal of Nutrition 81, 121–132.Google ScholarPubMed
Yergey, AL, Vieira, NE & Hansen, JW (1980) Isotope ratio measurements of urinary calcium with a thermal ionization probe in a quadrupole mass spectrometer. Analytical Chemistry 52, 1811–1814.CrossRefGoogle Scholar
Yergey, AL, Abrams, SA, Vieira, NE, Eastell, R, Hillman, LS & Covell, DG (1990) Recent studies of human calcium metabolism using stable isotopic tracers. Canadian Journal of Physiology and Pharmacology 68, 973–976.CrossRefGoogle ScholarPubMed
Yergey, AL, Abrams, SA, Vieira, NE, Aldroubi, A, Marini, J & Sidbury, JB (1994) Determination of fractional absorption of dietary calcium in humans. Journal of Nutrition 124, 674–682.CrossRefGoogle ScholarPubMed