Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-27T08:16:35.996Z Has data issue: false hasContentIssue false
  • English
  • Français

Postprandial factor VII metabolism: the effect of the R353Q and 10 bp polymorphisms

Published online by Cambridge University Press:  09 March 2007

Helen M. Roche ,
Irene L. Black ,
Enda Noone ,
Anne-Marie Tully ,
Alexander S. Whitehead  and
Michael J. Gibney
Helen M. Roche*
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
Irene L. Black
Affiliation:
Department of Genetics, Lincon Gate, Trinity College, Dublin 2, Republic of Ireland
Enda Noone
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
Anne-Marie Tully
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
Alexander S. Whitehead
Affiliation:
Department of Pharmacology, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104-6084, USA
Michael J. Gibney
Affiliation:
Unit of Nutrition, Department of Clinical Medicine, Trinity Centre for Health Sciences, St. James's Hospital, James's Street, Dublin 8, Republic of Ireland
*
*Corresponding author: Dr Helen M. Roche, fax +353 1 454 2043, email hmroche@tcd.ie
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Elevated levels of coagulation factor VII activity (FVIIc) are associated with increased risk of CHD. FVIIc is strongly determined by two polymorphisms (R353Q and 0/10 base pairs (bp)) and plasma triacylglycerol (TAG) concentrations. The Q and 10 bp polymorphisms show strong linkage disequilibrium and have been associated with lower levels of fasting FVII, but there has been little investigation of the effect of these genotypes on the postprandial FVII metabolism. The present study demonstrated that fasting activated factor VII (FVIIa) and factor VII antigen (FVIIag) levels were significantly lower in the heterozygotes carrying the Q and 10 bp alleles (n 12), than in the R/0 bp homozygotes (n 12) (43·0 (SE 4·8) v. 23·9 (SE 6·5) mU/ml and 85·7 (SE 5·4) v. 71·6 (SE 7·5) % respectively). During postprandial lipaemia there was a significant increase in FVIIa in R/0 bp homozygotes but not in the heterozygotes carrying the Q and 10 bp alleles. The proportion of FVIIa (FVIIa : FVIIag) increased in the homozygotes but not in the heterozygotes (2·04 (SE 0·35) v. 1·20 (SE 0·26) respectively). Therefore possession of the relatively common Q and 10 bp alleles is not associated with postprandial activation of FVII, which may in turn have a protective effect against CHD.

Keywords

Factor VIITriacylglycerolsGenetic polymorphism
Type
Short Communication
Information
British Journal of Nutrition , Volume 83 , Issue 5 , May 2000 , pp. 467 - 472
Copyright
Copyright © The Nutrition Society 2000

References

Bentzen, J,Bladbjerg, EM,de Maat, MPM and Marckmann, P (1996) Plasma factor VII levels are determined by polymorphisms in the factor VII gene. Fibrinolysis 10(Suppl. 2), 17–18.Google Scholar
Bernardi, F,Arcieri, P,Bertina, RM,Chiarotti, F,Corral, J,Pinotti, M,Prydz, H,Samama, M,Sandset, PM,Strom, R,Vicinte Garcia, V and Mariani, G (1997) Contribution of factor VII genotype to activated FVII levels. Differences in genotype frequencies between northern and southern European populations. Arteriosclerosis, Thrombosis and Vascular Biology 17, 2548–2553.Google Scholar
Bernardi, F,Marchetti, G,Pinotti, M,Arcieri, P,Barconcini, C,Papacchini, M,Zepponi, E,Ursicino, N,Chiarotti, F and Mariani, G (1996) Factor VII gene polymorphisms contribute about one third of the factor VII level variation in plasma. Arteriosclerosis, Thrombosis and Vascular Biology 16, 72–76.CrossRefGoogle ScholarPubMed
De Maat, MPM, Green, F,de Knijff, P,Jespersen, J and Kluft, C (1997) Factor VII polymorphisms in populations with different risks of cardiovascular disease. Arteriosclerosis, Thrombosis and Vascular Biology 17, 1918–1923.CrossRefGoogle ScholarPubMed
Friedewald, WT,Levy, RI and Fredrickson, DS (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clinical Chemistry 18, 499–502.Google Scholar
Frosst, P,Blom, HJ,Milos, R,Sheppard, CA,Matthews, RG,Boers, GHJ, den Heijer, M,Kluijtmans, LAJ, van den Hruvel, LP and Rosen, R (1995) A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nature Genetics 10, 111–113.Google Scholar
Ghaddar, M,Folsom, AR,Aleksic, N,Hearne, LB,Chambless, LE,Morrissey, JH and Wu, KK (1998) Correlation of fasting VIIa values with factor VII gene polymorphism, fasting and postprandial triglyceride levels, and subclinical carotid atherosclerosis.Circulation 98, 2815–2821.Google Scholar
Green, F,Kelleher, C,Wilkes, H,Temple, A,Meade, T and Humphries, S (1991) A common genetic polymorphism associated with lower coagulation factor VII levels in healthy individuals.Arteriosclerosis and Thrombosis 11, 540–546.Google Scholar
Humphries, SE,Lane, A,Green, FR,Cooper, J and Miller, GJ (1994) Factor VII coagulant activity and antigen levels in healthy men are determined by interaction between factor VII genotype and plasma triglyceride concentration. Arteriosclerosis and Thrombosis 14, 193–198.CrossRefGoogle ScholarPubMed
Humphries, S,Temple, A,Lane, A,Green, F,Cooper, J and Miller, G (1996) Low plasma levels of factor VIIc and antigen are more strongly associated with the 10 base pair promoter (-323) insertion than the glutamine 353 variant. Thrombosis and Haemostasis 75, 567–572.Google Scholar
Hunault, M,Arbini, AA,Lopaciuk, S,Carew, JA and Bauer, KA (1997) The Arg353Gln polymorphism reduces the level of coagulation factor VII.Arteriosclerosis, Thrombosis and Vascular Biology 17, 2825–2829.Google Scholar
Iacoviello, L,Di Castelnuovo, A,De Knijff, PD'Orazio, A, Amore, C,Arboretti, R,Kluft, C and Donati, MB (1998) Polymorphisms in the coagulation factor VII gene and the risk of myocardial infarction. New England Journal of Medicine 338, 79–85.CrossRefGoogle ScholarPubMed
Lane, A,Green, F,Sxarabin, PY,Nicaud, V,Bara, L,Humphries, S,Luc, G,Cambou, JP,Arveiler, D and Cambien, F (1996) Factor VII Arg/Gln 353 polymorphism determines factor VII coagulant activity in patients with myocardial infarction (MI) and control subjects in Belfast and France but is not a strong indicator of MI risk in the ECTIM study. Atherosclerosis 119, 119–127.Google Scholar
Larsen, LF,Bladbjerg, EM,Jespersen, J and Marckmann, P (1997) Effects of dietary fat quality on postprandial activation of blood coagulation factor VII. Arteriosclerosis, Thrombosis and Vascular Biology 17, 2904–2909.Google Scholar
Marchetti, G,Parracchini, P,Papacchini, M,Ferrati, M and Bernardi, F (1993) A polymorphism in the 5′ region of coagulation factor VII gene (F7) caused by an insertion decanucleotide. Human Genetics 90, 575–576.Google Scholar
Marckmann, P,Bladbjerg, EM and Jespersen, J (1998) Diet and blood coagulation factor VII — a key protein in arterial thrombosis.European Journal of Clinical Nutrition 52, 75–84.Google Scholar
Meade, TW,Ruddock, V,Stirling, Y,Chakrabarti, R and Miller, GJ (1993) Fibrinolytic activity, clotting factors, and long term incidence of ischaemic heart disease in the Northwick Park Heart Study. Lancet 342, 1076–1079.Google Scholar
Mennen, L,de Maat, M,Meijer, G,Zock, P,Grobbee, D,Kok, F,Kluft, C and Schouten, E (1998) Factor VIIa response to a fat-rich test meal does not depend on fatty acid composition: a randomized controlled trial.Arteriosclerosis, Thrombosis and Vascular Biology 18, 599–603.CrossRefGoogle Scholar
Mennen, LI,Schouten, EG,Grobbee, DE and Kluft, C (1996) Coagulation factor VII, dietary fats and blood lipids: a review. Thrombosis and Haemostasis 76, 492–499.Google ScholarPubMed
O'Hara, PJ, Grant, FJ,Haldeman, BA,Gray, CL,Insley, MY,Hagen, FS and Murray, MJ (1987) Nucleotide sequence of the gene coding for human factor VII, a vitamin K-dependent protein participating in blood coagulation. Proceedings of the National Academy of Sciences USA 84, 5158–5162.Google Scholar
Pollak, ES,Hung, HL,Godin, W,Overton, GC and High, KA (1996) Functional characterisation of the human factor VII 5′-flanking region. Journal of Biological Chemistry 271, 1738–1747.Google Scholar
Roche, HM and Gibney, MJ (1997) Postprandial coagulation factor VII activity: the effect of monounsaturated fatty acids. British Journal of Nutrition 77, 537–549.Google Scholar
Roche, HM,Zampelas, A,Knapper, JME, Webb, D,Brooks, C,Jackson, KG,Wright, JW,Gould, BJ,Kafatos, A,Gibney, MJ and Williams, CM (1998) Effect of long-term olive oil dietary intervention on postprandial triacylglycerol and factor VII metabolism. American Journal of Clinical Nutrition 68, 552–560.Google Scholar
Sanders, TAB, de Grassi, T,Miller, GJ and Humphries, SE (1999) Dietary oleic and palmitic acids and postprandial factor VII in middle-aged men heterozygous and homozygous for factor VII R353Q polymorphism. American Journal of Clinical Nutrition 69, 220–225.Google Scholar
Silveira, A,Green, F,Karpe, F,Blomback, M,Humphries, S and Hamsten, A (1994) Elevated levels of factor VII activity in the postprandial state: effect of the factor VII Arg-Gln polymorphism.Thrombosis and Haemostasis 72, 734–739.Google Scholar
Silveira, A,Karpe, F,Johnsson, H,Bauer, KA and Hamsten, A (1996) In vivo demonstration in humans that large postprandial triglyceride-rich lipoproteins activate coagulation factor VII through the intrinsic coagulation pathway. Arteriosclerosis, Thrombosis and Vascular Biology 16, 1333–1339.Google Scholar
Xie, X and Ott, J (1993) Testing linkage disequilibrium between a disease gene and marker loci. American Journal of Human Genetics 53, 1107–1112.Google Scholar