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Prophylactic nutritional modification of the incidence of diabetes in autoimmune non-obese diabetic (NOD) mice

Published online by Cambridge University Press:  09 March 2007

J. Hoorfar ,
K. Buschard  and
F. Dagnaes-Hansen
J. Hoorfar
Affiliation:
Boniholtgaurd Research Centre, Ry, Dennirirk
K. Buschard
Affiliation:
Boniholtgaurd Research Centre, Ry, Dennirirk
F. Dagnaes-Hansen
Affiliation:
Boniholtgaurd Research Centre, Ry, Dennirirk
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Abstract

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Experiments in rodent models of insulin-dependent diabetes mellitus (IDDM) suggest that destruction of pancreatic p cells can be both initiated and inhibited by certain environmental factors such as dietary constituents. We studied nutritional impact of certain protein sources of natural-ingredient, non-purified (NP) rodent diet on diabetes incidence and insulitis severity in the spontaneous diabetic, non-obese diabetic (NOD) mouse. Long-term ad lib. feeding of diets containing wheat flour (800 g/kg), and to a lesser extent soya-bean meal (400 g/kg), were associated with relatively high diabetes incidence (65 and 45% respectively), whereas a diet based on hydrolysed casein (HC; 200 g/kg) as the only source of protein significantly (compared with the wheat-flour diet) inhibited expression of diabetes (22 YO). Feeding a hypo-allergenic soya-bean-protein hydrolysate resulted in diabetes incidence and insulitis severity similar to that of the soya-bean-meal-fed group. This may indicate that protein hydrolysis per se may not be necessary for dietary modification of diabetes in the NOD mouse. The window of vulnerability to diabetogenic diets was found to be between weaning and about 70 d of age. In the diabetic mice insulitis was less frequent in the HC-fed group when compared with those fed NP (P = 0.04), soya- bean meal (P = 0.03), soya-bean-protein hydrolysate (P = 0.012) or wheat flour (P = 0.0002). In the non-diabetic mice the wheat-flour diet was associated with a high insulitis severity in comparison with the HC group (P = 0.004). Early avoidance of NP diet was associated with lower degree of insulitis in both diabetic (P = 0.00003) and non-diabetic mice (P =0.001) when compared with the mice fed on the HC diet later in life. These findings are contributing to further clarification of diabetes-promoting dietary constituents, which may have some nutritional implications for IDDM-susceptible children.

Keywords

Insulin-dependent diabetesProphylactic nutritionAutoimmunityNOD mice
Type
Nutritional Modification of Diabetes
Information
British Journal of Nutrition , Volume 69 , Issue 2 , March 1993 , pp. 597 - 607
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

American Institute of Nutrition (1977). Reports of the Ad Hoc Committee on Standards for Nutritional Studies. Journal of Nutrition 107, 1340–1348.CrossRefGoogle Scholar
Adler-Nissen, J. (1979). Determination of the degree of food protein hydrolysis by tri-nitro-benzene-sulfonic acid. Journal of Agriculture and Food Chemisiry 27, 1256–1262.CrossRefGoogle Scholar
Barnett, A. H., Eff, C., Leslie, R. D. G. & Pyke, D. A. (1981). Diabetes in identical twins. Diabetologia 20, 87–93.CrossRefGoogle ScholarPubMed
Bingley, P. J. & Gale, E. A. M. (1989). Rising incidence of lDDM in Europe. Diabetes Care 12, 289–295.CrossRefGoogle Scholar
Brogren, C.-H., Hoorfar, J. & Buschard, K. (1989). Early weaning and immunogenetic dietary proteins as important initiating factors for onset of diabetes in BB-rats. Diabetologia 32. 470A.Google Scholar
Buschard, K. (1991). The functional state of the beta cells in the pathogenesis of insulin-dependent diabetes mellitus. Autoimmunity 10, 65–69.CrossRefGoogle ScholarPubMed
Chamber, T. L. (1975). Coexistent coeliac disease, diabetes mellitus and hyperthyroidism. Archives of Disease in Childhood 50, 162–164.CrossRefGoogle Scholar
Coleman, D. L., Kuzava, J. E. & Leiter, E. H. (1990). Effect of diet on incidence of diabetes in non-obese diabetic mice. Diabetes 39, 432–436.CrossRefGoogle Scholar
Diabetes Epidemiology Research International Group (1988). Geographic patterns of childhood insulin-dependent diabetes mellitus. Diabetes 37, 1113–1119.CrossRefGoogle Scholar
Eisenbarth, G. S. (1986). Type I diabetes mellitus. A chronic autoimmune disease. New England Journal of Medicine 314, 1360–1368.Google ScholarPubMed
Elliott, R. B. & Martin, J. M. (1984). Dietary protein: a trigger of insulin-dependent diabetes in the BB rat? Diabetologia 26, 297–299.CrossRefGoogle ScholarPubMed
Elliott, R. B., Reddy, S. N., Bibby, N. J. & Kida, K. (1988). Dietary prevention of diabetes in non-obese diabetic mouse. Diabetologia 31, 62–64.CrossRefGoogle ScholarPubMed
Hoorfar, J., Scott, F. W. & Cloutier, H. E. (1990). Plant proteins and diabetes in the BB rat. Diabetes 39. Suppl. 1, 240A.Google Scholar
Hoorfar, J., Scott, F. W. & Cloutier, H. E. (1991). Dietary plant materials and development of diabetes in the BB rat. Journal of Nutrition 121, 908–916.CrossRefGoogle ScholarPubMed
Koivisto, V. A., Kuitunen, P., Tiilikanen, A. & Aakerblom, H. (1977). HLA antigens in patients with juvenile diabetes mellitus, coeliac disease and both of these diseases. Diabete Metabolisme 3, 49–53.Google Scholar
Leiter, E. H., Serreze, D. V. & Prochazka, M. (1990). The genetics and epidemiology of diabetes in NOD mice. Immnunology Today 11, 147–149.CrossRefGoogle ScholarPubMed
MacLaren, N., Schatz, D., Drash, A. & Grave, G. (1989). Initial pathogenic events in IDDM: Conference summary. Diabetes 38, 534–538.CrossRefGoogle Scholar
Makino, S., Kunimoto, K., Muraoka, Y., Mizushima, Y., Katagiri, K. & Tochino, Y. (1980). Breeding of a non-obese, diabetic strain of mice. Experimental Animals 29, 1–13.CrossRefGoogle ScholarPubMed
Scott, F. W., Cloutier, H. E., Souligny, J., Riley, W. J., Hoorfar, J. & Brogren, C.-H. (1989 a). Diet and antibody production in the diabetes-prone BB-rat. In Diabetes 1988, pp. 763–767 [Larkins, R., Zimmet, P. and Chisholm, D., editors]. Amsterdam: Elsevier Science Publishers.Google Scholar
Scott, F. W., Elliott, R. B. &Kolb, H. (1989 b). Diet and autoimmunity: prospects of prevention of type I diabetes. Diabetes Nutrition & Metabolism 2, 61–73.Google Scholar
Scott, F. W., Hoorfar, J. & Cloutier, H. E. (1990). Lymphocytes and macrophagesin BB rats fed diabetes-retardant or promoting diets. In Frontiers in Diabetes Research: Lessons From Animal Diabetes 111 pp 192–194 [Shafrir, E., editor]. London: Smith-Gordon and Company Ltd.Google Scholar
Scott, F. W., Mongeau, R., Kardish, M., Hatina, G., Trick, K. D. & Wojcinski, Z. (1985). Diet can prevent diabetes in the BB rat. Diabetes 34, 1059–1062.CrossRefGoogle ScholarPubMed
Smith, C., Van Megen, W., Twaalhofen, L. & Hitchcock, C. (1980). The determination of trypsin inhibitor levels in foodstuffs. Journal of the Science of Food and Agriculture 31, 341–350.CrossRefGoogle ScholarPubMed
Thain, M. E., Hamilton, J. R. & Ehrlich, R. M. (1974). Coexistence of diabetes mellitus and coeliac disease. Journal of Pediatrics 85, 527–528.CrossRefGoogle Scholar
Wilberz, S., Parthke, H. J., Dagnaes-Hansen, F. & Herberg, L. (1991). Persistent infection with mouse hepatitis virus reduces the incidence of diabetes in NOD mice. Diabetologia 34, 2–5.CrossRefGoogle Scholar