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Selenium (selenate) transport by human placental brush border membrane vesicles

Published online by Cambridge University Press:  09 March 2007

D. B. Shennan
D. B. Shennan
Affiliation:
Department of Human Anatomy, University of Oxford, South Parks Road, Oxford OX1 3QX
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Abstract

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1. Selenate uptake by human placental brush-border-membrane vesicles was studied in order to establish whether this anion shares a pathway with sulphate.

2. Selenate uptake was found to be saturable with respect to medium selenate and was inhibited by the anion exchange inhibitor 4,4′-diisothiocyano-stilbene-2,2′-disulphonate (DIDS).

3. Anions which have a similar tetrahedral shape to selenate, e.g. chromate, molybdate, tungstate and sulphate, were effective inhibitors of selenate uptake when added to the incubation medium.

4. Sulphate inhibited selenate influx in a dose-dependent fashion; moreover sulphate was found to be a competitive inhibitor of selenate uptake.

5. It is concluded that selenate and sulphate share a pathway for transport in the human placental microvillus membrane.

Type
Clinical and Human Nutrition papers: Studies in Man
Information
British Journal of Nutrition , Volume 59 , Issue 1 , January 1988 , pp. 13 - 19
Copyright
Copyright © The Nutrition Society 1988

References

Arduser, F., Wolffram, S. & Scharrer, E. (1985). Journal of Nutrition 115, 1203–1208.CrossRefGoogle Scholar
Boyd, C. A. R. & Lund, E. K. (1981). Journal of Physiology 315, 9–19.CrossRefGoogle Scholar
Boyd, C. A. R. & Shennan, D. B. (1986 a). Journal of Physiology 377, 15–24.CrossRefGoogle Scholar
Boyd, C. A. R. & Shennan, D. B. (1986 b). Journal of Physiology 379, 367–376.CrossRefGoogle Scholar
Cardin, C. J. & Mason, J. (1976). Biochimica et Biophysica Acta 394, 46–54.CrossRefGoogle Scholar
Cole, D. E. C. (1984). Biochemical and Biophysical Research Communications 123, 223–229.CrossRefGoogle Scholar
Gasko, O. P., Knowles, A. F., Schertzer, H. C., Suolinna, E. M. & Racker, E. (1976). Analytical Biochemistry 72, 57–65.CrossRefGoogle Scholar
Kauppila, A., Korpela, H., Makila, V.-M. & Yrjanheikki, E. (1987). British Medical Journal 294, 150–152.CrossRefGoogle Scholar
Lindblow-Kull, C., Kull, F. J. & Shrift, A. (1985). Journal of Bacteriology 163, 1267–1269.CrossRefGoogle Scholar
Shennan, D. B. (1987). Bioscience Reports (In the Press).Google Scholar
Shennan, D. B. & Boyd, C. A. R., (1986). Biochimica et Biophysica Acta 859, 122–124.CrossRefGoogle Scholar
Shennan, D. B., Boyd, C. A. R., Pledge, K. L. & Davis, B. (1987). In Cellular and Molecular Basis of Cystic Fibrosis [Quinton, P. M. and Mastella, G., editors]. San Francisco: San Francisco Press (In the Press).Google Scholar
Shennan, D. B., Davis, B. & Boyd, C. A. R. (1986). Pflügers Archiv 406, 60–64.CrossRefGoogle Scholar
Smith, N. C., Brush, M. G. & Luckett, S. (1974). Nature 252, 302–303.CrossRefGoogle Scholar