Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-10T14:26:45.915Z Has data issue: false hasContentIssue false
  • English
  • Français

Safety of etomidate bolus administration in patients with septic shock

Published online by Cambridge University Press:  11 May 2015

Rob Green  and
Sean K. Gorman
Rob Green*
Affiliation:
Department of Emergency Medicine, Department of Anesthesia, Division of Critical Care, Queen Elizabeth II Health Sciences Centre; Dalhousie University, Halifax, NS
Sean K. Gorman
Affiliation:
Department of Pharmacy, Capital District Health Authority and College of Pharmacy, Dalhousie University, Halifax, NS
*
Department of Medicine: Division of Critical Care and Department of Emergency Medicine, Queen Elizabeth II Health Sciences Centre, Dalhousie University, 377 Bethune Building, 1276 South Park Street, Halifax, NS B3H 2Y9; greenrs@dal.ca

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'

Keywords

adrenal insufficiencyemergency airway managementetomidatesepsis
Type
Knowledge to Practice • Des connaissances à la pratique
Information
Canadian Journal of Emergency Medicine , Volume 13 , Issue 2 , March 2011 , pp. 105 - 108
Copyright
Copyright © Canadian Association of Emergency Physicians 2011

References

REFERENCES

1.Zed, PJ, Abu-Laban, RB, Harrison, DW. Intubating conditions and hemodynamic effects of etomidate for rapid sequence intubation in the emergency department: an observational cohort study. Acad Emerg Med 2006;13:378–83, doi:10.1111/j.1553-2712.2006.tb00313.x.Google Scholar
2.Bergen, JM, Smith, DC. A review of etomidate for rapid sequence intubation in the emergency department. J Emerg Med 1997;15:221–30, doi:10.1016/S0736-4679(96)00350-2.Google Scholar
3.Reynolds, SF, Heffner, J. Airway management of the critically ill patient: rapid-sequence intubation. Chest 2005;127:1397–412, doi:10.1378/chest.127.4.1397.Google Scholar
4.Jackson, WL. Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock? Chest 2005;127:1031–8, doi:10.1378/chest.127.3.1031.CrossRefGoogle ScholarPubMed
5.Allolio, B, Dorr, H, Stuttmann, R, et al. Effect of a singlebolus of etomidate upon eight major corticosteroid hormones and plasma ACTH. Clin Endocrinol 1985;22:281–6, doi:10.1111/j.1365-2265.1985.tb03241.x.CrossRefGoogle Scholar
6.Marik, PE, Pastores, SM, Annane, D, et al. Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine. Crit Care Med 2008;36:1937–49, doi:10.1097/CCM.0b013e31817603ba.CrossRefGoogle ScholarPubMed
7.Annane, D, Sebille, V, Troche, G, et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000;283:1038–45.CrossRefGoogle ScholarPubMed
8.Annane, D, Sebille, V, Charpentier, C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002;288:862–71, doi:10.1001/jama.288.7.862.CrossRefGoogle ScholarPubMed
9.Sprung, CL, Annane, D, Keh, D, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008;358:111–24, doi:10.1056/NEJMoa071366.CrossRefGoogle ScholarPubMed
10.Delinger, RP, Levy, MM, Carlet, JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296–327, doi:10.1097/01.CCM.0000298158.12101.41.Google Scholar
11.Green, RS, Djogovic, D, Gray, S, et al. Canadian Association of Emergency Physicians Sepsis Guidelines: the optimal management of severe sepsis in Canadian emergency departments. CJEM 2008;10:443–59.Google Scholar
12.Jabre, P, Combes, X, Lapostolle, F, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet 2009;374: 293–300, doi:10.1016/S0140-6736(09)60949-1.CrossRefGoogle ScholarPubMed
13.Cuthbertson, BH, Sprung, CL, Annane, D, et al. The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 2009;35:1868–76, doi:10.1007/s00134-009-1603-4.CrossRefGoogle ScholarPubMed
14.Oglesby, AJ. Should etomidate be the induction agent of choice for rapid sequence intubation in the emergency department? Emerg Med J 2004;21:655–9, doi:10.1136/emj.2003.009043.Google Scholar
15.Franklin, C, Samuel, J, Hu, TC. Life-threatening hypotension associated with emergency intubation and the initiation of mechanical ventilation. Am J Emerg Med 1994;12:425–8, doi:10.1016/0735-6757(94)90053-1.CrossRefGoogle ScholarPubMed
16.Sivilotti, ML, Ducharme, J. Randomized, double-blind study on sedatives and hemodynamics during rapid-sequence intubation in the emergency department: the SHRED study Ann Emerg Med 1998;31:313–24, doi:10.1016/S0196-0644(98)70341-5.Google Scholar
17.Mort, TC. Complications of emergency tracheal intubation: hemodynamic alterations—part I. J Intensive Care Med 2007;22:157–65, doi:10.1177/0885066607299525.CrossRefGoogle ScholarPubMed
18.Marchick, MR, Kline, JA, Jones, AE. The significance of nonsustained hypotension in emergency department patients with sepsis. Intensive Care Med 2009;35:1261–4, doi:10.1007/s00134-009-1448-x.CrossRefGoogle ScholarPubMed
19.Katz, MH. Multivariable analysis: a practical guide for clinicians. Cambridge (UK): Cambridge University Press; 1999.Google Scholar