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Can Behenic Acid (C22:0) Levels be a Prognostic Factor in Glial Tumors?

Published online by Cambridge University Press:  23 September 2014

Metin Kaplan ,
Mehmet Koparan ,
Aysel Sari ,
Sait Ozturk ,
Serpil Kozan Kaplan  and
Fatih Serhat Erol
Metin Kaplan*
Affiliation:
Firat University, School of Medicine, Department of Neurosurgery, Malatya, Turkey
Mehmet Koparan
Affiliation:
Firat University, School of Medicine, Department of Neurosurgery, Malatya, Turkey
Aysel Sari
Affiliation:
Faculty of Arts and Sciences, Department of Chemistry, Elazig, Malatya, Turkey
Sait Ozturk
Affiliation:
Firat University, School of Medicine, Department of Neurosurgery, Malatya, Turkey
Serpil Kozan Kaplan
Affiliation:
Malatya State Hospital, Department of Pathology, Malatya, Turkey
Fatih Serhat Erol
Affiliation:
Firat University, School of Medicine, Department of Neurosurgery, Malatya, Turkey
*
Firat Universitesi T1p Fakültesi Hastanesi, beyin ve Sinir Cerrahisi Klinigi, 23200, Elaz1ğ, Turkiye. Email: mtkaplan02@yahoo.com.tr.
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Abstract

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Background:

Inhibition of fatty acid synthase leads to apoptosis in cancers, which leads to high levels of fatty acid synthesis. This indicates that cancer cells depend on fatty acid in order to survive. In this study, we investigated whether or not there was a relationship between the glial tumor grade and free fatty acid level of tumor tissue.

Methods:

Twenty patients who had high grade glial tumors and 20 patients who had low grade glial tumors, were included in the study. Tumors samples were obtained intraoperatively in order to measure the fatty acid levels. The fatty acids were studied in three groups: saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids. They were analyzed with gas chromatography.

Results:

The oleic acid, linoleic acid, eicosadienoic acid, arachidonic acid, and docosadienoic acid levels were high in the tumor tissue of low grade tumors. The myristic acid, palmitic acid, stearic acid, alpha linoleic acid, eicosenoic acid, dihomo-gamma-linolenic acid, docosahexaenoic acid, and ceramide levels were high in the tumor tissue of high grade glial tumors. However, none of these high values were statistically significant. The high values of behenic acid, a saturated fatty acid, in low grade glial tumors were statistically significant.

Conclusion:

High levels of behenic acid in patients with low grade glial tumor is important as it indicates persistence of the tissue integrity and tissue resistance. behenic acid levels can be a prognostic factor in glial tumors.

Résumé

RÉSUMÉ Contexte:

L'inhibition de l'acides gras synthase provoque l'apoptose dans les cancers ce qui entraîne un taux élevé de synthèse des acides gras. Ceci indique que les cellules cancéreuses dépendent des acides gras pour leur survie. Dans cette étude, nous avons examiné s'il existait une relation entre le grade de la tumeur gliale et le niveau d'acides gras libres dans le tissu tumoral.

Méthode:

Vingt patients porteurs de tumeurs gliales de haut grade de malignité et 20 patients porteurs de tumeurs gliales de bas grade de malignité ont été inclus dans l'étude. Des échantillons de tumeurs ont été obtenus pendant la chirurgie afin de mesurer les niveaux d'acides gras. Les acides gras ont été étudiés en trois groupes : les acides gras saturés, les acides gras monoinsaturés et les acides gras polyinsaturés. L'analyse a été réalisée par chromatographie en phase gazeuse.

Résultats:

les niveaux d'acide oléique, d'acide linoléique, d'acide eicosadiénoïque, d'acide arachidonique et d'acide docosadiénoïque étaient élevés dans le tissu tumoral provenant des tumeurs de bas grade de malignité. Les niveaux d'acide myristique, d'acide palmitique, d'acide stéarique, d'acide alpha-linoléique, d'acide eicosanoïque, d'acide dihomo-gamma-linolénique, d'acide docosahexaénoïque et de céramides étaient élevés dans le tissu tumoral provenant de gliomes de haut grade de malignité. Cependant, aucune de ces valeurs élevées n'atteignait le seuil de la signification au point de vue statistique. Les valeurs élevées d'acide béhénique, un acide gras saturé, dans les tumeurs gliales de bas grade de malignité étaient significatives au point de vue statistique.

Conclusions:

Cet article présente des données témoins pour les différentes composantes de la GDRA en vue de faciliter le diagnostic des maladies du système nerveux autonome.

Type
Original Article
Information
Canadian Journal of Neurological Sciences , Volume 40 , Issue 6 , November 2013 , pp. 854 - 856
Copyright
Copyright © The Canadian Journal of Neurological 2013

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