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Chorea

Published online by Cambridge University Press:  05 January 2016

Harold L. Klawans
Harold L. Klawans*
Affiliation:
Department of Neurological Sciences, Rush-Presbyterian St, Lukes Medical Center, Chicago
*
Department of Neurological Sciences, Rush-Presbyterian St, Lukes Medical Center, 1725 W. Harrison St., Chicago, IL., U.S.A. 60612
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Abstract:

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A variety of neurotransmitters have been implicated in the pathophysiology of chorea as exemplified by Huntington's chorea. These include dopamine, serotonin, acetylcholine, GABA and a variety of neuropeptides including substance P and somatostatin. Despite biochemical data that suggests that alterations in other neurotransmitters may be of greater significance, pharmacologic data still supports a major role of dopamine in the actual clinical manifestation of chorea.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 14 , Issue S3 , August 1987 , pp. 536 - 540
Copyright
Copyright © Canadian Neurological Sciences Federation 1987

References

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