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Dementia in Movement Disorders

Published online by Cambridge University Press:  18 September 2015

H. Teräväinen ,
M. Hietanen ,
J. Stoessl  and
D.B. Calne
H. Teräväinen
Affiliation:
Division of Neurology, Department of Medicine, UBC Health Sciences Centre Hospital, University of British Columbia, Vancouver and the Department of Neurology, University of Helsinki, Finland
M. Hietanen
Affiliation:
Division of Neurology, Department of Medicine, UBC Health Sciences Centre Hospital, University of British Columbia, Vancouver and the Department of Neurology, University of Helsinki, Finland
J. Stoessl
Affiliation:
Division of Neurology, Department of Medicine, UBC Health Sciences Centre Hospital, University of British Columbia, Vancouver and the Department of Neurology, University of Helsinki, Finland
D.B. Calne*
Affiliation:
Division of Neurology, Department of Medicine, UBC Health Sciences Centre Hospital, University of British Columbia, Vancouver and the Department of Neurology, University of Helsinki, Finland
*
The University of British Columbia, Health Sciences Centre Hospital, 2211 Wesbrook Mall, Vancouver, B.C., Canada V6T 1W5
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Abstract:

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Of all the movement disorders, Huntington's disease has been most consistently associated with dementia, while it is only over the last decade that intellectual and cognitive decline have been recognized as common features of Parkinson's disease. It is now known that the pathology in these two conditions reflects differential involvement of the striatum. The Huntington lesion is primarily in the caudate, while the Parkinson lesion preferentially affects the putamen. Both conditions have more diffuse pathology, and dementia may also occur in a wide range of other extrapyramidal diseases, such as progressive supranuclear palsy, the parkinsonism-dementia complex of Guam, and certain spinocerebellar degenerations. Clinicopathological correlations will be reviewed in these disorders of primarily subcortical pathology, and comparisons will be made with Alzheimer's disease, a disorder of predominantly cortical pathology.

Type
Imaging of Demented Subjects
Information
Canadian Journal of Neurological Sciences , Volume 13 , Issue S4 , November 1986 , pp. 546 - 558
Copyright
Copyright © Canadian Neurological Sciences Federation 1986

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