Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-26T06:08:34.518Z Has data issue: false hasContentIssue false
  • English
  • Français

A Double-Blind Cross-over Trial of Amantadine Hydrochloride in Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

A. Filla ,
G. De Michele ,
G. Orefice ,
F. Santarelli ,
L. Trombetta ,
S. Banfi ,
F. Squitieri ,
G. Napolitano ,
D. Puma  and
G. Campanella
A. Filla*
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. De Michele
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. Orefice
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
F. Santarelli
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
L. Trombetta
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
S. Banfi
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
F. Squitieri
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. Napolitano
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
D. Puma
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
G. Campanella
Affiliation:
Department of Neurology, Second School of Medicine, Federico II University, Naples and Sanatrix Neurological Institute (G.N., D.P.), Venafro, Italy
*
Prof. Filla, Clinica Neurologica, Seconda Facoltà di Medicina, via Pansini 5, 80131, Napoli, Italy
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We performed a double-blind cross-over study with amantadine hydrochloride in 12 patients with Friedreich's disease and 2 with autosomal dominant cerebellar ataxia. Patients were randomly assigned to a placebo-amantadine or amantadine-placebo sequence. The interval between the treatments was two weeks. Patients were graded according to a functional ataxia scoring scale and videotaped in basal conditions and 90 min after a single oral dose of 100 mg amantadine or placebo. Three evaluators independently scored the videotapes. Statistical analysis showed no significant effect of amantadine in Friedreich's disease.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 1 , February 1993 , pp. 52 - 55
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

1.Harding, AE.Classification of the hereditary ataxias and spastic paraplegias. Lancet 1983; i: 1151–1155.CrossRefGoogle Scholar
2.Filla, A, De, Michele G, Caruso, G, Marconi, R, Campanella, G.Genetic data and natural history of Friedreich's disease: a study of 80 Italian patients. J Neurol 1990; 237: 345–351.CrossRefGoogle ScholarPubMed
3.Chamberlain, S, Shaw, J, Rowland, A, et al.Mapping of mutation causing Friedreich's ataxia to human chromosome 9. Nature 1988; 334: 248–249.CrossRefGoogle ScholarPubMed
4.Rich, SS, Wilke, P, Schut, L, Wance, G, Orr, HT.Spinocerebellar ataxia: localization of an autosomal dominant locus between two markers on human chromosome 6. Am J Hum Genet 1987; 41: 524–531.Google ScholarPubMed
5.Peterson, PL, Saad, J, Nigro, MA.The treatment of Friedreich's ataxia with amantadine hydrochloride. Neurology 1988; 38: 1478–1480.CrossRefGoogle ScholarPubMed
6.Botez, MI, Young, SN, Botez, T, Pedraza, OL.Treatment of heredo-degenerative ataxias with amantadine hydrochloride. Can J Neurol Sci 1991; 18: 307–311.CrossRefGoogle ScholarPubMed
7.Campanella, G, Filla, A, De, Falco FA, et al.Friedreich's ataxia in the south of Italy: a clinical and biochemical survey of 23 patients. Can J Neurol Sci 1980; 7: 351–358.CrossRefGoogle ScholarPubMed
8.Canter, GJ, De, la Torre R, Mier, M.A method for evaluating disability in patients with Parkinson's disease. J Nerv Ment Dis 1961; 133: 143–147.CrossRefGoogle ScholarPubMed
9.Hayden, FG, Minoche, A, Spyker, DA, Hoffman, HE.Comparative single-dose pharmacokinetics of amantadine hydrochloride and rimantadine hydrochloride in young and elderly adults. Antimicrob Agents Chemoter 1985; 28: 216–221.CrossRefGoogle Scholar
10.Bradley, WG, Badger, GJ, Tandan, R, et al.Double-blind controlled trials of Cronassial in chronic neuromuscular diseases and ataxia. Neurology 1988; 38: 1731–1739.CrossRefGoogle ScholarPubMed