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Lipoamide Dehydrogenase in Friedreich's Ataxia Fibroblasts

Published online by Cambridge University Press:  18 September 2015

S. B. Melançon ,
M. Potier ,
L. Dallaire ,
G. Fontaine ,
B. Grenier ,
B. Lemieux ,
G. Geoffroy  and
A. Barbeau
S. B. Melançon
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
M. Potier
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
L. Dallaire
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
G. Fontaine
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
B. Grenier
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
B. Lemieux
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
G. Geoffroy
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
A. Barbeau*
Affiliation:
Le Centre de Recherche Pédiatrique, Hôpital Sainte-Justine, Montréal; and L'Institut de Recherche Clinique de Montréal, Le Centre Hospitaller Universitaire de Sherbrooke
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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Summary:

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Lipoamide dehydrogenase was measued in cultivated skin fibroblasts from twelve patients with Friedreich's ataxia and nine normal controls. No difference in specific activity, subcellular distribution and Vmax or Km was observed between patients and controls.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 115 - 118
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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