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Organization of the Mouse Motor Cortex Studied by Retrograde Tracing and Intracortical Microstimulation (ICMS) Mapping

Published online by Cambridge University Press:  18 September 2015

Cheng-Xiang Li  and
Robert S. Waters
Cheng-Xiang Li
Affiliation:
Department of Anatomy and Neurobiology, University of Tennessee, Memphis, College of Medicine, 875 Monroe Avenue, Memphis, TN, U.S.A. 38163
Robert S. Waters*
Affiliation:
Department of Anatomy and Neurobiology, University of Tennessee, Memphis, College of Medicine, 875 Monroe Avenue, Memphis, TN, U.S.A. 38163
*
Department of Anatomy and Neurobiology, University of Tennessee, Memphis, 875 Monroe Avenue, Memphis, Tennessee, U.S.A., 38163
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Abstract:

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The motor representation of the body musculature was studied in 11 adult mice by using ICMS. The motor responses elicited from both granular and agranular cortical fields showed that the mouse motor cortex is topographically organized; however, within the representation of individual body-parts the movements are multiply represented. In addition, several sites were encountered where more than one movement was elicited at the same stimulus threshold. The locations of pyramidal cells contributing axons to the pyramidal tract were examined by means of retrograde tracing with HRP injected into the cervical enlargement. This procedure labeled neurons only in lamina V in granular and agranular cortical fields. The similarities between the organization of motor cortex demonstrated in this study and the organization in the rat suggest that the rat and mouse share a common plan of rodent motor cortical organization.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 1 , February 1991 , pp. 28 - 38
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

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