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Single-Blind Study of Dystrophin Staining in Carriers of Duchenne Muscular Dystrophy

Published online by Cambridge University Press:  18 September 2015

Francois P. Bernier ,
Cheryl R. Greenberg ,
William C. Halliday  and
Klaus Wrogemann
Francois P. Bernier*
Affiliation:
Departments of Pediatrics & Child Health (F.C.B., C.R.G.), Human Genetics (F.C.B., C.R.G., K.W.), Pathology (F.C.B., W.C.H.) and Biochemistry and Molecular Biology (F.C.B., K.W.), University of Manitoba, Winnipeg
Cheryl R. Greenberg
Affiliation:
Departments of Pediatrics & Child Health (F.C.B., C.R.G.), Human Genetics (F.C.B., C.R.G., K.W.), Pathology (F.C.B., W.C.H.) and Biochemistry and Molecular Biology (F.C.B., K.W.), University of Manitoba, Winnipeg
William C. Halliday
Affiliation:
Departments of Pediatrics & Child Health (F.C.B., C.R.G.), Human Genetics (F.C.B., C.R.G., K.W.), Pathology (F.C.B., W.C.H.) and Biochemistry and Molecular Biology (F.C.B., K.W.), University of Manitoba, Winnipeg
Klaus Wrogemann
Affiliation:
Departments of Pediatrics & Child Health (F.C.B., C.R.G.), Human Genetics (F.C.B., C.R.G., K.W.), Pathology (F.C.B., W.C.H.) and Biochemistry and Molecular Biology (F.C.B., K.W.), University of Manitoba, Winnipeg
*
Department of Biochemistry and Molecular Biology, University of Manitoba, Winnipeg, Manitoba, Canada R3E 0W3
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Abstract:

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A single-blind study of dystrophin staining in skeletal muscle was performed in 13 biopsies from carriers of Duchenne Muscular Dystrophy (DMD) and controls. The results indicate that immunohistochemical analysis of dystrophin staining is a valuable diagnostic test for DMD carriers when DNA for testing is unavailable from critical family members or is uninformative, when creatine kinase (CK) values are conflicting or when CK values must be used in isolation.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue 1 , February 1993 , pp. 44 - 47
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

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