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Taurine in Cerebrospinal Fluid in Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

B. Lemieux ,
R. Giguere ,
A. Barbeau ,
S. Melancon  and
D. Shapcott
B. Lemieux
Affiliation:
le Centre Hospitalier de l'Université de Sherbrooke; the Clinical Research Institute of Montreal and the Hôpital Sainte-Justine, Montreal
R. Giguere
Affiliation:
le Centre Hospitalier de l'Université de Sherbrooke; the Clinical Research Institute of Montreal and the Hôpital Sainte-Justine, Montreal
A. Barbeau*
Affiliation:
le Centre Hospitalier de l'Université de Sherbrooke; the Clinical Research Institute of Montreal and the Hôpital Sainte-Justine, Montreal
S. Melancon
Affiliation:
le Centre Hospitalier de l'Université de Sherbrooke; the Clinical Research Institute of Montreal and the Hôpital Sainte-Justine, Montreal
D. Shapcott
Affiliation:
le Centre Hospitalier de l'Université de Sherbrooke; the Clinical Research Institute of Montreal and the Hôpital Sainte-Justine, Montreal
*
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec, Canada H2W 1R7
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In a previous study we reported low values of taurine and aspartic acid in the CSF of patients with Friedreich's ataxia, when the results were compared to the literature. Further studies have revealed that tinforetold difficulties with the advertised methodology of sequential multi-sample amino acid analysis were responsible for low values in the determination of these two amino acids in the small volumes necessary for CSF. A corrected method is presented. With the latter method the differences disappear for CSF taurine and aspartic acid, but they remain valid for the previously reported blood and urine values in Friedreich's ataxia. GABA levels are also normal in Friedreich's ataxia CSF.

Type
Quebec Cooperative Study of Friedreich's Ataxia
Information
Canadian Journal of Neurological Sciences , Volume 5 , Issue 1 , February 1978 , pp. 125 - 129
Copyright
Copyright © Canadian Neurological Sciences Federation 1978

References

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