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Feasibility of Biological Specimen Collection for the Canadian Longitudinal Study on Aging (CLSA) Biorepository*

Published online by Cambridge University Press:  01 September 2009

Cynthia M. Balion ,
Parminder S. Raina ,
Christina Wolfson ,
Susan A. Kirkland ,
Judy L. Keys ,
Lauren E. Griffith ,
Amélie Pelletier ,
Jennifer Uniat  and
Matthew J. McQueen
Cynthia M. Balion
Affiliation:
Hamilton Regional Laboratory Medicine Program Department of Pathology and Molecular Medicine, McMaster University
Parminder S. Raina*
Affiliation:
McMaster Evidence-based Practice Center, McMaster University Department of Clinical Epidemiology and Biostatistics, McMaster University
Christina Wolfson
Affiliation:
Division of Clinical Epidemiology, McGill University Health Centre Department of Epidemiology & Biostatistics and Occupational Health, and Department of Medicine, McGill University
Susan A. Kirkland
Affiliation:
Department of Community Health & Epidemiology, Dalhousie University Department of Medicine, Dalhousie University
Judy L. Keys
Affiliation:
Clinical Research and Clinical Trials Laboratory
Lauren E. Griffith
Affiliation:
McMaster Evidence-based Practice Center, McMaster University Department of Clinical Epidemiology and Biostatistics, McMaster University
Amélie Pelletier
Affiliation:
Division of Clinical Epidemiology, McGill University Health Centre
Jennifer Uniat
Affiliation:
Division of Clinical Epidemiology, McGill University Health Centre
Matthew J. McQueen
Affiliation:
Hamilton Regional Laboratory Medicine Program Department of Pathology and Molecular Medicine, McMaster University Clinical Research and Clinical Trials Laboratory
*
†Correspondence and requests for offprints should be sent to: / La correspondance et les demandes de tirés-à-part doivent être adressées à : Parminder S. Raina, PhD Professor/Director McMaster University, Evidence-based Practice Center 1280 Main St. W. DTC Room 310 Hamilton, Ontario, L8S 4L8 praina@mcmaster.ca
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Abstract

Biological specimen collection is an integral part of many longitudinal epidemiological studies. It is important to achieve high participant satisfaction for continuing involvement, and high sample quality for accurate biomarker measurement. We conducted a study to evaluate these issues on the sample collection proposed for the Canadian Longitudinal Study on Aging (CLSA). There were 85 participants recruited, and 65 attended either a hospital laboratory or private laboratory. Approximately 100 mL of blood and a random urine specimen were collected from each participant for a total of 2,108 sample aliquots. Quality standards were met for more than 90 per cent of samples and were similar for samples collected in both laboratories. More than 90 per cent of participants rated satisfaction with the collection as being good or excellent, and 84 per cent would be willing to repeat the collection in one to three years.

Résumé

La collecte de spécimens biologiques est une partie intégrale de beaucoup d’études épidémiologiques longitudinales. Il est important d’obtenir un haut taux de satisfaction de la part des participants pour que leur participation soit continue et pour assurer une qualité élevée des échantillons pour avoir des mesures précises pour les biomarqueurs. Nous avons réalisé une étude pour évaluer ces questions sur la collecte d’échantillons proposée pour l’Étude longitudinale canadienne sur le vieillissement (ÉLCV). Parmi les 85 participants recrutés, 65 ont été dirigés vers un laboratoire d’hôpital ou un laboratoire privé. Environ 100 mL de sang et un prélèvement aléatoire d’urine ont été collectés pour chaque participant, pour un total de 2 108 aliquots d’échantillon. Les niveaux de qualité ont été atteints pour plus de 90 % des échantillons et étaient semblables pour les échantillons collectés dans les deux laboratoires. Plus de 90 % des participants ont exprimé que leur satisfaction par rapport à la collecte était bonne ou excellente, et 84 % serait prêts à répéter la collecte dans un à trois ans.

Keywords

collection des spécimensELCVsangurineHPOGqualitéspecimen collectionCLSAbloodurineOGTTquality
Type
Articles
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 28 , Issue 3: Special Issue on the Canadian Longitudinal Study on Aging (CLSA) , September 2009 , pp. 261 - 274
Copyright
Copyright © Canadian Association on Gerontology 2009

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Footnotes

*

Funding for the Canadian Longitudinal Study on Aging was provided by the Canadian Institutes of Health Research (CIHR), Le Fonds de la recherche en santé du Québec (FRSQ) – Réseau québécois de recherche sur le vieillissement.

Parminder Raina is the recipient of a Canadian Institutes of Health Research Investigator award, an Ontario Premier’s Research Excellence award, and holds a Labarge Chair in Research and Knowledge Application for Optimal Aging at McMaster University.

We wish to thank the following physicians and their staff for recruiting participants for this study: Dr. C. D. C. Bankay, Dr. O. A. Dada, Dr. L. H. Keeton, Dr. A. R. DeRubeis, Dr. T. Creatchman, and Dr. A. I. Crosthwaite. We also wish to thank the staff of the Clinical Research and Clinical Trials Laboratory for collection of samples at the Hamilton General Hospital, as well as Gamma-Dynacare for collection of samples at the private laboratory. The investigators gratefully acknowledge Lynda Booker for assisting with patient recruitment and Francois Fournier for laboratory and physician screening in Montreal.

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