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Alcohol Withdrawal: Neuroadaptation and Sensitization

Published online by Cambridge University Press:  07 November 2014

Howard C. Becker
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Abstract

Repeated episodes of alcohol withdrawal may exacerbate the severity of future withdrawal occurrences. The progressive intensification of withdrawal symptoms may be manifested as a kindling-like mechanism. This sensitization process may reflect persistent perturbation in excitatory and inhibitory influences on brain function. Relapse is also thought to be affected by the kindling mechanism. Successive alcohol withdrawal experiences may also lead to neurologic damage and cognitive impairments. We review the research findings regarding the alcohol withdrawal kindling hypothesis and the implications of the kindling process on mechanisms of dependence, alcohol withdrawal treatment strategies, and the long-term repercussions of alcoholism.

Type
Feature Articles
Information
CNS Spectrums , Volume 4 , Issue 1: Neural Mechanisms of the Alcohol Abuse Cycle , January 1999 , pp. 38 - 40,57-65
Copyright
Copyright © Cambridge University Press 1999

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