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Angioedema and Maculopapular Eruptions Associated with Carbamazepine Administration

Published online by Cambridge University Press:  07 November 2014

Alby Elias ,
Subramoniam Madhusoodanan ,
David Pudukkadan  and
James T. Antony
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Abstract

Cutaneous rashes and eruptions can be caused by many medications, including carbamazepine. The presentation can be varied depending on severity. Cutaneous eruptions occur in 3% of individuals administered carbamazepine. Angioedema, a rare side effect of carbamazepine, involves vascular leakage in dermis and subcutis mediated by immunoglobulin E and/or bradykinins. Angioedema is more common in females and in the third decade of life. We report the case of a 27-year-old Indian woman who developed maculopapular rash and angioedema secondary to carbamazepine administration. The patient responded successfully to withdrawal of the drug and treatment with antihistamines. Due to the potentially life-threatening complications of this condition and the increasing use of anticonvulsants in the treatment of mood disorders, psychiatrists must be aware of the diagnosis and treatment of this condition.

Type
Case Report
Information
CNS Spectrums , Volume 11 , Issue 5 , May 2006 , pp. 352 - 354
Copyright
Copyright © Cambridge University Press 2006

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