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Bipolar Disorder: Emotional Dysregulation and Neuronal Vulnerability

Published online by Cambridge University Press:  07 November 2014

Dan J. Stein ,
Neil Horn ,
Rajkumar Ramesar  and
Jonathan Savitz
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Abstract

Bipolar disorder is clinically characterized by fluctuating affect, and neuropsychologically by impairment in executive functions. Such phenomena are consistent with the centrality of emotional dysregulation and impulsivity to bipolar disorder. They are also consistent with a key role for prefrontal-subcortical (striatal-thalamic) and associated limbic circuitry in its mediation. Furthermore, there is growing data on the cellular mechanisms contributing to neuronal vulnerability in this mediating circuitry.

Type
Pearls in Clinical Neuroscience
Information
CNS Spectrums , Volume 14 , Issue 3 , March 2009 , pp. 122 - 126
Copyright
Copyright © Cambridge University Press 2009

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